Fruity Smoothie Yogurt
Fruity Smoothie Yogurt
Kiwi 200 g
Raspberry 150 g
Yogurt 140 g
Ice
Syrup 150 g
Kiwi
Syrup
Ice
Raspberry
Ice
Syrup
Yogurt
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Why Is It So Hard to Make a Male Birth Control Pill? - Duration: 5:35.[♪ INTRO ]
At a meeting of endocrinologists this month, researchers presented new work that suggests
they're one step closer to a male birth control pill!
Do you feel like you've heard this news before?
Well, that's probably because you have.
Scientists have been looking into a safe, reversible kind of male birth control for
decades and they've gotten close, but not quite there.
Even here on SciShow, we've reported on things like chromatin remodeling, hormone
injections, and a dissolvable gel that plugs up the vas deferens — AKA the sperm tubes.
Researchers call these treatments "male birth control" for short, because they're
tested in cisgender males who are making sperm.
So why's it so tricky to make a male pill?
The short answer is: it's a lot easier to stop one egg a month than millions of sperm
a day.
The female birth control pill has been around since 1960 — nearly 60 years ago!
And it's one of many options out there.
The pill has synthetic hormones — either a combination of estrogen and progestin, or
progestin alone.
So it stabilizes hormone levels and prevents the spike in estrogen that normally happens
midway through the menstrual cycle, setting off a chain of events that lead to ovulation.
Without that spike, no egg is released and no babies are made.
Very rarely, the female birth control pill can have serious side effects, like blood
clots or heart problems.
But it has some potential health benefits too, like reducing bone thinning, anemia,
or risk of some cancers.
Other than condoms, vasectomies, and withdrawal… there aren't many male birth control options.
And nothing based on hormones has panned out.
On average, men release around 180 million sperm every time they ejaculate.
It only takes one to fertilize an egg and get their partner pregnant.
So… that's a lot of sperm to deal with.
Instead of physically stopping them, like a condom does, male pills aim to lower the
sperm count.
Basically, stopping the production of sperm cells, but leaving the rest of the semen alone.
And the basic strategy for this is kind of counterintuitive.
It turns out that if you give men lots of testosterone, they stop making sperm.
Sperm are produced in the testes, which are also testosterone factories.
So testosterone levels are really high in there, like 25-125 times higher than in blood.
And sperm need those high concentrations of testosterone to develop correctly.
But when a dude gets an injection or a pill of extra testosterone, the brain and pituitary
gland sense that body-wide levels are high enough and shut off production in the testes.
With no testosterone being made down there, the concentration drops, and sperm don't
develop.
Previous attempts at male hormonal contraception involved weekly or monthly doses of synthetic
testosterone.
And if you add progestin, these injections, implants, or patches worked even better.
But even though they were good at stopping sperm production, there were drawbacks.
It was difficult to get synchronized, steady levels of testosterone and progestin.
And weekly, or even monthly, injections aren't as convenient as a daily pill you can take
at home.
Birth control doesn't work if you can't get people to use it.
Plus, some men had unpleasant side effects like pain at the injection site, acne, or
changes in mood including more aggression.
Researchers were wary of giving the necessary big doses of oral testosterone, too, because
previous studies have shown that this can be really hard on the liver.
Not to mention, the body clears this orally-delivered testosterone pretty quickly so pills have
to be taken twice a day.
So what makes this new male pill different?
This research is a team effort from scientists at the University of Washington and the Los
Angeles Biomedical Research Institute.
And they presented their work at the recent Endocrine Society meeting in Chicago.
Their experiments focused on a compound called dimethandrolone undecanoate or DMAU.
It has a different structure than testosterone that lets it hang around in the body longer,
which keeps levels steady even if it's only taken once a day.
DMAU is considered a pro-drug, because it's converted to an active molecule that interacts
with the body after it's ingested.
In this case, enzymes called esterases change DMAU into dimethandrolone or DMA.
And DMA binds to the same hormone receptors as testosterone and progestin throughout the
body.
Just like testosterone given in a pill or injection, DMA tricks the body into producing
less testosterone in the testes, so concentrations there drop and sperm aren't produced.
When the researchers tested this in animals it worked pretty well.
It even stopped sperm production in rabbits, who have legendary fertility.
Sounds promising, right?
This research is getting a lot of attention, but it's still in the early stages.
Here's how the recent experiment went down: researchers had 83 men between ages 18 and
50 take DMAU pills daily for 28 days.
They also took blood samples before and after, to check for hormone levels and other health
markers like cholesterol.
And the scientists found that the testosterone in the participants' blood decreased to
very low levels — levels that suggested that sperm production was effectively shut
down.
Now, it's important to note though that they didn't actually measure sperm count.
This study was mostly to test whether the pill is safe.
And it seems like it is!
The participants didn't report any significant changes in sex drive, sexual function, or
any serious side effects with their livers or kidneys, which were all potential concerns.
Some men had mild weight gain and increased red blood cell count.
And some had slightly decreased levels of the good form of cholesterol, but these weren't
serious problems.
The research team is starting another study soon that will follow men taking the DMAU
pill for a longer period of time, and take semen samples to measure their sperm production.
So whether it's this team or another than makes the breakthrough... safe, convenient,
reversible male birth control will definitely be a pretty big deal.
And you know who else is a big deal?
SR Foxley, our SciShow President of Space.
He's actually pretty humble, but he's a big deal to us because he helps make SciShow
possible every month so we can bring you the latest in science news and dig deep into big
questions.
Thanks SR!
You are the best!
And to learn more about how you can help us out too, check out patreon.com/scishow.
[♪ OUTRO ]
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[SPECIAL EASTER] Sunflower Spinach and Cheese Puff Pastry Tart Easy Recipe - Duration: 2:23.SUNFLOWER PUFF PASTRY TART
2 SMALL EGGS (OR JUST A BIG ONE)
SALT AND BLACK PEPPER
40 GRAMS OF PARMIGIANO REGGIANO
COOK 300 GRAMS OF FROZEN SPINACH IN A SALTED BOILING WATER FOR ABOUT 6/7 MINS
DRAIN AND LET THEM COOL
ADD 250 GRAMS OF RICOTTA
LAY ONE SHEET OF PUFF PASTRY
SLIGHTLY PRESS A GLASS IN THE CENTRE TO MARK WHERE YOUR ARE GOING TO PUT THE FILLING
PRICK PASTRY WITH A FORK
PLACE THE MIXTURE, AND LEAVE A SPACE FROM THE CENTER
PLACE THE OTHER SHEET OF PUFF PASTRY AND GENTLY PRESS THE CENTER AND THE OUTER EDGES
BRUSH THE TOP WITH ONE EGG MIXED WITH SOME MILK
BAKE IN A PREHEATED OVEN AT 400°F/200°C FOR 20-25 MINS
SUBSCRIBE TO MY CHANNEL :)
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My Milestones: Libby Neely, Silver Saddles Rider and Volunteer - Duration: 3:33.My name is Libby Neely and I'm an equine massage therapist, and I've been volunteering at Milestones
since July of 2017.
It's, uh, it's thrilling, it's exciting as could be.
It's very freeing.
Well, it's back to it's freeing.
I never thought I could do this at my age.
It's been quite an experience.
Coordination for one.
[Laughs] The overall bonding with the horse and the animals is pretty incredible.
Incredible again.
It's exceptional.
It's an awesome feeling.
My husband sees a happier me.
He can always tell when I've been to the barn and been riding; I come home smiles.
Incredibly.
I came in here with almost zero knowledge on riding, and the instructors and everybody's
been great.
They just really guide you step by step.
That's a tough one.
[Laughs] They all are exceptional in their own personalities.
I have ridden maybe three, four of them, but I'd have to lean towards Champ.
He was my first horse.
I've been to in the spring-- in the summer, I'm sorry, they have like a fair tour-- farm
tour, and they do all the farms, and that was really a fun event to attend.
And they also have what's called the "Mane Event", it's their main fundraiser, and that
was a fun evening.
I came on board as a massage therapist and massaged the horses, and once I was introduced
to everybody and the horses and realized that I was able to ride, that was a -- that opened
a whole new chapter for me.
That was really cool.
Everybody's been here before me so they all had the knowledge and the riding experience,
and I kinda came on as the rookie, so I'm kinda learning from all of them.
But everybody just really enjoys the program.
It's very satisfactory.
You walk out and it's just an incredible feeling.
Yeah.
To see the horses and to see the volunteers and even with the children riding, it's really
neat to see them.
I don't actually volunteer with the children with the special needs, but after I massage
the horses I do watch some of the classes and what the children and their response when
riding the horses and what they get out of it, it's pretty incredible.
I took a course back last spring, over in Round Hill, Virginia, and, uh, to get my certification
in Equine Massage, and that's how I was introduced to Milestones.
It's been really a neat experience with the horses.
Each of them get different responses, and, uh, I feel like I've been really been able
to help the horses.
It helps relieve the tension.
We had one horse over here that you couldn't even touch him or his little ears, and now
he's full body contact with people.
It's very relaxing to them and to me too.
Look at this.
[Laughs] All of this.
All the horses.
I just enjoy being here.
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GTX 1060 6GB | Far Cry 5 Walktrought Part 1 - Duration: 48:29.GTX 1060 6GB Far Cry 5 Walktrought Part 1
GTX 1060 6GB Far Cry 5 Walktrought Part 1
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General James "Mad Dog" Mattis Breaks The Silence And Drops Major Announcement - Duration: 17:51.General James "Mad Dog" Mattis Breaks The Silence And Drops Major Announcement
Daily Caller revealed that Secretary of Defense Mattis is engrossed with where the U.S. will
put every one of those surrendered forces.
"I needed to lay out the problem," Mattis told reporters assigned to cover him at the
conference, where he will open the session with a speech Friday afternoon.
"We have hundreds of prisoners who don't have quite the same amount of zeal they once
pronounced when they were winning that they would fight to the death.
It seems like hundreds of them are not quite that committed."
He went ahead to state that ISIS prisoners are cooling their heels in a temporary holding
tank at this moment and that he means to raise the issue at the Munich meeting.
Mattis clarified that he is "under no illusion" that any convenient solution can be found
to reduce the requirement for more jail space.
The general at that point said that endeavors to expand the per capita defense of NATO nations
to be spot on course, as eight member states will accomplish the two percent target this
year while another 14 are on track to arrive by 2024.
"Year-on-year across the alliance, 2017 saw the largest growth … as a percentage
of GDP, and the largest real growth in a quarter century," Mattis declared.
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Lexus GS 450h Luxury Line Mark Levinson, Blind Spot Monitor - Duration: 0:56. For more infomation >> Lexus GS 450h Luxury Line Mark Levinson, Blind Spot Monitor - Duration: 0:56.-------------------------------------------
Crooked Stilo - A Tu Manera For more infomation >> Crooked Stilo - A Tu Manera-------------------------------------------
Amazon helped us reach more people: Ray J - Duration: 4:14. For more infomation >> Amazon helped us reach more people: Ray J - Duration: 4:14.-------------------------------------------
CSE Expert Take - Facebook Data Breach - Duration: 2:50.Anytime that you've ever used a Facebook app
Like the "Pick a celebrity who looks like you"
What you're doing is you're giving that app permission to look at your profile
and the reason why people are creating those apps is not because it's fun
it's because they can mine your data and then mine the data of all of your friends and so forth.
Facebook makes its money by creating profiles of its users
and then selling that data to people or using that data to target ads.
In order to make their platform more attractive,
they also enable other parties to do similiar things.
So it's really not unprecedented.
Especially if you look at data leaks in the last year.
Equifax may seem fairly unrelated, but it's really not.
In that case that was actually gross incompetence.
In Facebook's case, Cambridge Analytica was just using Facebook the way it was intended.
Nothing has changed.
If you're an average user for Facebook, all this is doing is raising awareness what Facebook is
what it does, what the apps you use on Facebook have the power to do, and it really highlights the fact that
Facebook is not in the interest of your privacy.
If you tell Facebook that you don't want an app to be able to access your data anymore,
all Facebook can do is prevent that app from accessing your data in the future.
If you want the data that has already been collected by it, you actually have to make a request to that company.
The only way to combat that is to look through every app that you've ever enabled on your Facebook
and then call those companies and hope they'll delete your data.
There's really not a good mechanism here to actually delete data that's stored by third parties.
Even if you don't think that you're tech saavy
or don't think that you have a vested interest, you do.
Because the internet and social media networks are becoming so deeply imbedded
in daily life for people particularly in the United States and Europe and places like that,
it is greatly in within your interest to understand the privacy implications of what you do online.
It also highlights the fact that there are companies like Facebook that
I don't want to say are intent on preventing you from being able to understand that, but it's certainly in their interest to.
And I think that it highlights that there's maybe potential for legislation or something like that could better protect users.
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GNTM als Single-Börse? Klaudia mit K. ist in Flirtlaune! - Duration: 2:54. For more infomation >> GNTM als Single-Börse? Klaudia mit K. ist in Flirtlaune! - Duration: 2:54.-------------------------------------------
Crowdfunding page for fired FBI deputy director close to $500K - Duration: 4:04.A crowdfunding campaign to cover legal costs for Andrew McCabe,
the former FBI deputy director fired two days before he planned to retire and
obtain a full pension, was approaching half a million dollars Friday,
almost double its $250,000 goal.
In fact, the original goal for the legal defense fund was $150,000,
which was later raised to $250,000, and by Friday more than 10,000 people had
donated more than $460,000.
An updated description called the support "overwhelming, humbling,
and deeply appreciated." The funds will go toward "a number of congressional
inquiries that he will be required to respond to,
as well as the broader Office of the Inspector General (OIG) investigation that is
ongoing, and any potential lawsuits he might consider," the page said.
"[McCabe] and his family continue to deal with the very public and extended
humiliation that the Administration, and the President personally,
have inflicted on them over the past year," the page read.
A description on the page clarified that it was the only official one raising
funding for McCabe, despite imitation pages.
Extra money raised will go toward charities of the family's choosing,
the page said, and although it's unclear what will happen to McCabe's pension and
healthcare benefits from more than 20 years in the FBI,
"no funds raised for the Andrew McCabe Legal Defense Fund will be used for anything
beyond his defense of the allegations against him.
He will continue to fight for the pension and benefits he deserves,
rather than accept any crowdfunding for that purpose," it read.
"Not in my worst nightmares did I ever dream my FBI career would end this way,"
McCabe later wrote in the Washington Post.
In an official statement from Attorney General Jeff Sessions on McCabe's
termination March 16, he said investigations concluded that McCabe had made "an
unauthorized disclosure to the news media and lacked candor — including under oath
— on multiple occasions."
"The FBI expects every employee to adhere to the highest standards of honesty,
integrity, and accountability.
As the OPR proposal stated, 'all FBI employees know that lacking candor under oath
results in dismissal and that our integrity is our brand,'" Sessions said.
McCabe issued his own statement saying he would no longer keep silent — and kept
that promise by writing the op-ed.
"For the last year and a half, my family and I have been the targets of an
unrelenting assault on our reputation and my service to this country.
Articles too numerous to count have leveled every sort of false,
defamatory and degrading allegation against us.
The President's tweets have amplified and exacerbated it all.
He called for my firing.
He called for me to be stripped of my pension after more than 20 years of service.
And all along we have said nothing, never wanting to distract from the mission of
the FBI by addressing the lies told and repeated about us."
"No more," McCabe said.
McCabe joined the FBI in 1996.
Beginning in 2016, he served as deputy director of the FBI under former FBI
Director James Comey.
McCabe became acting director after Comey was fired and then resumed his role as
deputy director when President Donald Trump's appointee for director, Chris Wray,
was sworn in the late summer of 2017.
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