Monday, May 22, 2017

Youtube daily report May 22 2017

This simulator of the fireflies.

It creates the illusion of fireflies, which are enclosed in a glass cup.

In the darkness creates a nice color effect.

Let's see how it is all an illusion created.

Inside the cup is a simple printed circuit board on which are several LEDs and a few resistors.

You see, the design is very simple.

Glass cup I bought on sale and originally had probably serve as a vase.

But in a form not cuts through the colorful beauty.

LEDs are controlled by Arduino and shift register 74HC595.

Shift Register I have modified that it can be easily used with the breadboard.

All outputs of the shift register are on the one side, facilitating the construction.

We only need a few wires sufficient length to be able to connect the Arduino and LEDs.

For more infomation >> Arduino - Fireflies in a jar - Duration: 1:38.

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Autoboy Blackbox : Dashcam App - 05-21-2017 12:20:11 FDR Drive, New York, NY 10028, USA - Duration: 5:01.

For more infomation >> Autoboy Blackbox : Dashcam App - 05-21-2017 12:20:11 FDR Drive, New York, NY 10028, USA - Duration: 5:01.

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Autoboy Blackbox : Dashcam App - 05-21-2017 12:15:08 John Finley Walk, New York, NY 10065, USA - Duration: 5:01.

For more infomation >> Autoboy Blackbox : Dashcam App - 05-21-2017 12:15:08 John Finley Walk, New York, NY 10065, USA - Duration: 5:01.

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╔» • RE-Eats • ► Naked Chicken Chips & Chickstar From Taco Bell ◄ «╗ - Duration: 5:17.

For more infomation >> ╔» • RE-Eats • ► Naked Chicken Chips & Chickstar From Taco Bell ◄ «╗ - Duration: 5:17.

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BIGGER Biceps Made Easy (SUPER FAST SUPER-SETS!) - Duration: 7:07.

What's up champ! I'm Vince Del Monte of

GeneExpressionTraining.com

In this video we've got BIGGER biceps made easy.

Easy in the context that it's not going

to take up a lot of room OR you're not

going to need a lot of exercise

equipment. So you have no excuse whether

you're a beginner or an advanced guy

[Music]

I'm going to take you through this workout

Show you exactly how to do it.

I'm going to show you exactly what to think

about. I'm going to give you some

specific tips to make sure you pick the

right weight so whether you want to go

from thirteen or fourteen inch arms or

17- 18 inch arms, this workout will get

the job done.

Alright. So before we jump into this

super fast, super efficient super-set

workout, I want to quickly talk about super

sets. There's five kind of super set

workouts. There's probably more but

there's five most popular ones that

you're familiar with. Method 1 is when

we pre-fatigue the muscle so you might

do a pec fly with a bench press. We have

post fatigue where we may do a chin-up

within a hammer curl. We have super

setting antagonist muscles so like a

chest movement with a back movement. We

also have upper lower super sets where

we maybe do a shoulder press then with a

squat.So there's a lot of different ways

to superset. The superset method we're

using today is called Isolation Superset.

So we're isolating the same body part

with two exercises so we're doing two

bicep exercises back to back but they're

not just any random exercises. They're

exercises that challenge different parts

of the strength curve. So we're not just

selecting two exercises that hit the

shorten range and then two that hit the

lengthen range because that would be

redundant and that would create

unnecessary fatigue. We want to hit all

ranges of the strength curve so that's

how I've set this workout up. So let's

get into it.

Exercise number 1 here are incline

dumbbell curls and what you're going to

be doing here is a set of ten and then

we're going to stand up and we're going

to be doing standing hammer curls

alternating until failure. Alright. These

are our first two exercises. It's very

very simple guys. You're going to do

three sets of ten and then you're going

to go right into the superset to failure.

Last week when I did this workout I did

3 sets of 10 with 35's the

entire workout. So this week knowing that

I want to coax my gains

I'm starting a little bit heavier. I'm

going to aim for just my first set with

40 pounds alright. That's the name of the

game when you're trying to get better.

We're not trying to make leaps and

bounds in our progress. We just want micro

progressions. As you can see I get my ten

reps and then I rest for ten seconds and

then

I stand up and I go right into an

alternating dumbbell hammer curl.

So when you're doing these hammer curls I really

want you to think about keeping an

upright torso, contracted abs so you're

not using your trunk to swing and doing

your best to create all the movement at

your elbow. A little bit at the shoulders

is fine too.

After superset one we rest for 90

seconds. You notice I've got my stop

watch here and then we do this again.

Now anticipating the fatigue that's going to

set in I've gone down to 35's. Now that's

okay. A lot of people are going to ask

what if I can't complete 10 reps. This is

a metabolic stress workout so the goal

of this workout is to create a lot of

fatigue within the muscle. So it's more

important that you hit your goal reps

than keeping the weight heavy. So it's

okay if you have to drop the weight from

set to set. I prefer that you start off

heavier and drop the weight as the sets go

on. That's going to promote a better

quality workout. You'll notice on this

third set when you're doing the incline

curls you're going to really start

seeing the most amount of fatigue

obviously. So this is where it's okay to

even goe to an alternative grip to get

those last few reps as you can see that

I'm doing here. And then finally when we

stand up for the final hammer curls

you're just contracting as hard as you

can keeping all the tension on your

muscles. You know the name of the game

here guys is time under tension with

good quality loads. Alright. Time under

tension. We've got to make the muscles

burn, Alright. So now once you're done

that you're halfway through the workout.

The next combo are prone incline reverse

dumbbell curls superset with prone

supine dumbbell curls. As you can see

what I'm doing here. Now the goal here

guys on the first exercise is to

challenge that brachialis that

brachioradialis. The brachialis is an

interesting muscle because it gets

underneath the biceps so when you

develop it, it helps push your biceps out

kind of like the soleus underneath the

calf. When you develop the soleus you

built that push that Gastroc out too.

So this is very important if you want

bigger arms. You can't neglect your

reverse curls. After 10 seconds we go

right into our supine curls. As you

guys likely know and can feel the

hardest parts at the top. That's the best

part so don't waste what I call the

don't wait to the end. Alright so we

want to really hang tough through that

top range try and hang out there get a

good contraction. Don't rush through the

best part of the movement. Also don't

waste the negative on the way back down.

So controlling the weight upwards and

downwards try not to swing. Think about

squeezing the muscles not swinging the

weight. So that's it guys. Six sets on

arms. Four good exercises hitting all

points of the strength curve. What you'll

notice is that this workout really

increases a lot of lactic acid

production and lactic acid helps trigger

the anterior pituitary gland that helps

release growth hormone which is a very

anabolic hormone that helps leaning down

and build muscle. And if you feel a

little pukie during this workout, that's

pretty normal because of the amount of

work we did in a short period of time,

that lactic acid really can cause that

like oh I kind of feel like feel like

I'm gonna puke.Iif you're experiencing

that, that's a good sign. It means you're

working hard. So a lot of people report

that training smaller body parts more

frequently is a great recipe for faster

results.

I found this myself but the key is to

keep the volume lower just as we've

prescribed like in this video. You can't

do a 2 hour arm workout three times

per week. That's just stupid.

But if you do these shorter more intense

workouts, the superset style workouts,

doing this two three times per week

might be the exact recipe you need to

build bigger biceps. Alright guys I hope

you guys enjoyed that workout. If you did

be sure to give it a thumbs up. If you

want me to replicate what I did with

biceps for triceps let me know in the

comment section below and I'll get it

done for you guys. You want a complete

full blown guide to building bigger arms

click the link on the screen or the

first link in the description box and

it'll take you to a page to read more

about my vanity specialization program

for arms. Full blown arms specialization

routines regardless of your level so

that you can take those arms to the next

level. This is the kind of stuff I've had

to resort to to build up my scrawny arms.

Alright. I was not gifted with good arms

but that's okay. I've had to learn how to

train smarter and now the results are

more rewarding when I do see gains.

Alright thank you so much for

watching. I'll see you guys next time.

[Music]

For more infomation >> BIGGER Biceps Made Easy (SUPER FAST SUPER-SETS!) - Duration: 7:07.

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Life Hack| How to open a bottle without an opener or a corkscrew - Duration: 3:51.

Hey guys!

What's up friends!

I'm Sergey the interesting

And I'm Ficus

And today we'll show you 20 ways

To open a bottle without a corkscrew or an opener

Alright so the very first way to open a bottle is simple

For this you need a bottle of coke and a friend's leg

For this method we need a paper

and we'll twist it like this

And now we can boldly open it

like this

Here's the oldest grandfather's way of opening the bottle with eyes

And now I'll show you how to open a wine bottle using a screw, screw-driver and pliers

Now we'll open the bottle with the help of a shoe by knocking it to the tree

As a result the liquid will hit the corkscrew during the impact and the cork should come out slowly by slowly

Let's try

need some more hitting

There you go, Look!

Well! Keep hitting

That's it

The next way is with the help of marker, it can also be a pencil, pen etc. and a shoelace

At first using the marker we press the cork inside

Good! And now I'll show how to take out this cork from there. And so we push the lace inside, under the cork

And we try to pull it out

Like this

But it's better to use a satin ribbon because it's thinner and it doesn't bend so much like the lace

Therefore, it'll be much easier and quicker

Yeah friends it was the most stupid and lame method for opening a wine bottle

We showed you 20 ways to open a bottle if you don't have an opener or a corkscrew

If you liked this video be sure to put the Like and subscribe to our channel

Also write us in the comments about your interesting ways to open a bottle without using a corkscrew or an opener

Yes, because may be we missed out something. We love you all

Bye

For more infomation >> Life Hack| How to open a bottle without an opener or a corkscrew - Duration: 3:51.

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Zombs.io BEST base | Tower bypass limit Glitch | Wave 100+ | ZOMBS.io - Duration: 15:42.

zombs.io best base

For more infomation >> Zombs.io BEST base | Tower bypass limit Glitch | Wave 100+ | ZOMBS.io - Duration: 15:42.

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Piramide Con Decenas Sorteo Miercoles 24 de Mayo 2017 Loteria Nacional : Loteria del 24 de Mayo 2017 - Duration: 1:26.

For more infomation >> Piramide Con Decenas Sorteo Miercoles 24 de Mayo 2017 Loteria Nacional : Loteria del 24 de Mayo 2017 - Duration: 1:26.

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HD Footage Танец хоровод бабочек Футаж - Duration: 0:41.

For more infomation >> HD Footage Танец хоровод бабочек Футаж - Duration: 0:41.

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Iron Man (2008) Movie Clip | Tony Stark Press Conference | Cheeseburger Scene | HD 4K(+SUBTITLES) - Duration: 4:38.

Watch it, coming up here.

Are you kidding me with this? Get rid of them.

Hmm.

Your eyes are red. A few tears for your long-lost boss?

Tears of joy. I hate job hunting.

Yeah, vacation's over.

Where to, sir?

Take us to the hospital, please, Happy. - No.

No? Tony, you have to

go to the hospital. - No is a complete answer.

The doctor has to look at you. - I don't have to do anything.

I've been in captivity for three months.

There are two things I want to do. I want an American cheeseburger,

and the other... - That's enough of that.

Is not what you think. I want you to call for a press conference now.

Call for a press conference? - Yeah.

What on earth for? - Hogan, drive. Cheeseburger first.

Look at this!

Tony.

We were going to meet at the hospital.

No, I'm fine.

Look at you!

You had to have a burger, yeah? - Well, come on.

You get me one of those?

There's only one left. I need it.

Hey, look who's here! Yeah!

Miss Potts? - Yes.

Can I speak to you for a moment?

I'm not part of the press conference,

but it's about to begin right now.

I'm not a reporter.

I'm agent Phil Coulson,

with the Strategic Homeland Intervention, Enforcement

and Logistics Division.

That's quite a mouthful.

I know. We're working on it.

You know, we've been approached already by the DOD, the FBI, the CIA...

We're a separate division with a more specific focus.

We need to debrief Mr. Stark about the circumstances of his escape.

I'll put something in the book, shall I?

Thank you.

Uh...

Hey, would it be all right if everyone sat down?

Why don't you just sit down? That way you can see me, and I can...

A little less formal and...

What's up with the love-in?

Don't look at me.

I don't know what he's up to.

Good to see you.

Good to see you.

I never got to say goodbye to Dad.

I never got to say goodbye to my father.

There's questions that I would have asked him.

I would have asked him how he felt about what this company did.

If he was conflicted, if he ever had doubts.

Or maybe he was every inch the man we all remember from the newsreels.

I saw young Americans killed

by the very weapons I created to defend them and protect them.

And I saw

that I had become part of a system that is comfortable with zero accountability.

Mr. Stark! - Hey, Ben.

What happened over there?

I had my eyes opened. I came to realize that I have more

to offer this world than just making things that blow up.

And that is why, effective immediately, I am shutting down

the weapons manufacturing division of Stark International

until such a time as I can decide what the future of the company will be.

I think we're gonna be selling a lot of newspapers.

What direction it should take, one that I'm comfortable with

and is consistent with the highest good for this country, as well.

What we should take away from this is that Tony's back!

And he's healthier than ever.

We're going to have a little internal discussion

and we'll get back to you with the follow-up.

Where is he? - He's inside.(coolestclips4k)

For more infomation >> Iron Man (2008) Movie Clip | Tony Stark Press Conference | Cheeseburger Scene | HD 4K(+SUBTITLES) - Duration: 4:38.

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Eugene Airport - Travel Lane County's 2017 Convention Leadership Award - Duration: 2:54.

Every day visitors arrive and depart

from the Eugene Airport, but did you know

that this bustling travel hub is also a

valuable partner for booking meetings

and conventions in the Eugene

Springfield metro area? Over the last

several years the Eugene Airport has

helped secure numerous conferences

including the Aircraft Facility Maintenance Conference,

the Oregon Airport Management Association

Annual Conference

and the AAAE Sixel Digital Media Summit

and they aren't resting on their laurels.

In September 2017 the Northwest Chapter

of the American Association of Airport Executives

will also come to Eugene-Springfield because

of the Eugene Airport's innovative

operations and industry outreach.

"So it's important to the airport to bring the

conference to Eugene for a number of

reasons. We were really active with

AAAE which is the American

Association of Airport Executives in

that they're the host of the conference

but we've also been kind of pioneers as

far as airport social media so it just

gave us an opportunity to showcase our

airport in the community."

The success of the Eugene Airport and its recent growth

increases its value for the local

community. "I think that the Eugene

Airport is a really important part of

this community. They want to make sure

that folks don't have to go two hours

away to Portland. They're a smaller

airport with a really big heart, so being

able to have this conference here and

showcase that is a really great

testament to how important the airport

is in the community." The Eugene Airport

has partnered with Travel Lane County to

support group marketing efforts by

providing air vouchers for planner

giveaways. They provide support for many

national conferences flying into the

Eugene Airport such as neighborhoods USA

and the International Town and Gown

Association. "Travel Lane County is one of

our community partners and we all work

together to promote the airport

and promote the community. I think it's,

you know, one of the best-kept secrets in

Oregon and I think it shows because more

people are using the airport." With a

newly expanded airport terminal

welcoming touches include increased

dining options, floor-to-ceiling glass

windows, improved airport flow from

security checkpoints to baggage and an

expanded baggage claim area. The Eugene

Airport flies above and beyond simple

ingress and egress with its welcoming

atmosphere, making it an excellent

selling point for bringing large groups

to our community. We are pleased to

acknowledge and thank the Eugene Airport

for their exemplary industry

contributions and present them with our

2017 Eugene, Cascades & Coast

Convention Leadership Award.

For more infomation >> Eugene Airport - Travel Lane County's 2017 Convention Leadership Award - Duration: 2:54.

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TOP 5 BENDY AND THE INK MACHINE SONGS! BUILD OUR MACHINE, ANGEL OF THE STAGE, CAN I GET AN AMEN, TLT - Duration: 16:21.

*music*

For more infomation >> TOP 5 BENDY AND THE INK MACHINE SONGS! BUILD OUR MACHINE, ANGEL OF THE STAGE, CAN I GET AN AMEN, TLT - Duration: 16:21.

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What is Personalized Medicine and how is it used? Penn State Health - Duration: 1:59.

Personalized medicine is the process by

which we understand an individual's

genetic makeup in a way that allows us

to help predict the person's

susceptibility to disease or decide what

would be the optimum treatment for that

individual. The Institute for

Personalized Medicine opened it's doors

four years ago. About 30 different

clinical areas at the Medical Center

work with the Institute to provide more

precise care. Here's how it works

with patients. The oncologist will first

determine whether or not they have

cancer and if so, one of the first things

that they will do is take a sample of

that tumor, extract the DNA, send it off

to a company to have them determine the

genetic changes that have occurred and

on the basis that information integrate

that into the choice of therapeutic

treatments. So patients receive

personalized treatment. We don't treat

all breast cancers the same. We do an

analysis of the genetic changes that

have occurred in that particular tumor

and on the basis of that we can

prescribe different therapeutic regimens

and this has been extremely effective

particularly in the targeted therapies

that have been developed in conjunction

with genotyping over the last five years

of being able to have a remarkable

effectiveness in reversing the effects

of the cancer. And that's Dr. Claxton's

goal for his patients. I think that what

we're doing is going to change the way

other people elsewhere do this sort of

work. I think it's ultimately going to

find its way into day to day routine

leukemia evaluation and treatment.

I think that what we're doing here is very

innovative. We feel it's absolutely

essential for the future.

For more infomation >> What is Personalized Medicine and how is it used? Penn State Health - Duration: 1:59.

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How are clinical trials regulated nationally and at Penn State Health? - Duration: 1:12.

There's a set of regulatory laws and

rules that come from the federal

government called the common rule. And

they essentially lay out the ethical

regulations that any institution

receiving federal funding has to follow

in order to protect human subjects and

research. We also follow a set of rules

called good clinical practice which are

international rules for the ethical and

scientific conduct of research.

So federal guidelines are in place what

does the Medical Center do them to

regulate trials. So the Medical Center

has a Human Subjects protection office

and the role of that office is to make

certain that our institution is in

compliance with all of those rules and

regulations to protect human subjects.

It also provides the structure for our

institutional review boards and those

boards are independent boards that are

composed of scientists, clinicians,

nonscientists, community members who review

all of the human subjects research at

our institution to make sure that

they're ethically and scientifically

sound and that we protect the human

subjects to the degree possible.

For more infomation >> How are clinical trials regulated nationally and at Penn State Health? - Duration: 1:12.

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Fiat Doblò Cargo 1.3 MULTIJET ACTUAL,AIRCO,ELEK RAMEN, CENTR VERGR. MEERDERE FOTO"S VOLGEN - Duration: 0:50.

For more infomation >> Fiat Doblò Cargo 1.3 MULTIJET ACTUAL,AIRCO,ELEK RAMEN, CENTR VERGR. MEERDERE FOTO"S VOLGEN - Duration: 0:50.

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Surfing World Games: Cherif Fall Sénégal - Euskadi Surf TV - Duration: 0:56.

For more infomation >> Surfing World Games: Cherif Fall Sénégal - Euskadi Surf TV - Duration: 0:56.

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Iron Man (2008) Movie Clip | Making The Mark 2 Armor | 'JARVIS Holotable' Scene | HD 4K(+SUBTITLES) - Duration: 3:48.

Jarvis, you up?

For you, sir, always.

I'd like to open a new project file, index as Mark Two.

Shall I store this on the Stark Industries Central Database?

Actually, I don't know who to trust right now.

Till further notice, why don't we just keep everything

on my private server?

Working on a secret project, are we, sir?

I don't want this winding up in the wrong hands.

Maybe in mine, it can actually do some good.

Next. Up.

Not in the boot, Dummy. Right here. You got me?

Stay put. Nice.

You're of no benefit at all. Move down to the toe. I got this.

Okay, I'm sorry, am I in your way?

Up.

Screw it. Don't even move.

You are a tragedy.

Okay, let's do this right.

Start mark, half a meter, and back and center.

Dummy, look alive. You're on standby for fire safety.

You, roll it.

Okay. Activate hand controls.

We're gonna start off nice and easy.

We're gonna see if 10% thrust capacity achieves lift.

And three,

two,

one.

Up two. All right, set that.

I've been buzzing you. Did you hear the intercom?

Yeah, everything's... What?

Obadiah's upstairs. - Great!

What would you like me to tell him? - Great. I'll be right up.

Okay.

I thought you said you were done making weapons.

It is.

This is a flight stabilizer. It's completely harmless.

I didn't expect that.(coolestclips4k)

For more infomation >> Iron Man (2008) Movie Clip | Making The Mark 2 Armor | 'JARVIS Holotable' Scene | HD 4K(+SUBTITLES) - Duration: 3:48.

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Why should you consider participating in a clinical trial? Penn State Health - Duration: 0:42.

In many instances it allows the

individual to be able to receive some

treatment or therapy that they wouldn't

otherwise be allowed to receive and

be able to receive. And how do people

find out about these research studies?

Well it's really you want to talk to

your physician or your care provider.

While over 70% of individuals in the

country say that they would participate

in clinical trials, really, only about

one to two percent do. So reach out to

your care provider and find out what

opportunities there may be available to

you and as well you'll want to go to

StudyFinder.PSU.edu. And there's all the

information as far as all the different

clinical trials, research studies that are

involved there.

For more infomation >> Why should you consider participating in a clinical trial? Penn State Health - Duration: 0:42.

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What is a placebo and how does it work? - Penn State Health - Duration: 0:27.

Most people understand placebo is a

sugar pill so in other words it's an

inactive pill that looks exactly like

the study drug and it gives us an

opportunity to give one set of patients

or subjects an active study drug and

another set the placebo so that we can

actually compare the true good and bad

effects of that study drug.

For more infomation >> What is a placebo and how does it work? - Penn State Health - Duration: 0:27.

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What's the difference between clinical trials and research studies Penn State Health - Duration: 0:41.

Clinical trials are one specific type of

research study but there's also other

types of studies such as public health

research. And this can differ because

these studies typically involve healthy

volunteers to participate and they study

things outside of the clinical setting.

Okay. Tell me about healthy

volunteers. Healthy volunteers can

participate in both clinical trials and

research studies, correct? Absolutely

healthy volunteers are really

important to research studies. They can

help us understand the difference

between patients who have a disease and

who don't and even help us determine

appropriate treatments or disease

prevention.

For more infomation >> What's the difference between clinical trials and research studies Penn State Health - Duration: 0:41.

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What is the consent process for participating in a clinical trial? - Penn State Health - Duration: 0:52.

In some process is vital to making

certain that we're conducting ethical

research because for most studies the

subjects have to volunteer to be in the

studies they have to be able to say no I

don't want to participate and they can't

really be forced to participate. And so,

the consent process is a verbal and

written process usually that provides

the adequate information to potential

subjects to allow them to make a

reasonable decision about whether they

want to participate in a research study.

That information includes what the

studies about, why are we doing that

study, what we expect out of a volunteer,

what the volunteer can expect out of the

researchers and what the potential risks

and benefits would be for that study.

For more infomation >> What is the consent process for participating in a clinical trial? - Penn State Health - Duration: 0:52.

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LIVERPOOL-MIDDLESBROUGH (Watching the game in Cochabamba-Bolivia)|| LA ANGOSTURA || VLOG # 40 - Duration: 14:00.

We're going to a place called Angostura

To see this game

And we want to show you

Because we know that there are people who are coming to Cochabamba to live

So, we're going to show you where you can find the transportation to go to Angostura

We are in the intersection of : Barrientos and Guayamerìn

Right at the corner

In the street upfront as you can see

right here

There are a lot of trufis (buses) which go to different villages

like : TARATA.. CLIZA

You go onboard

And tell the driver that you'll get off in Angostura

And you get out there

It doesn't take long to get to Angostura

We'll see how long it takes to get there

The bus is on the move, it's 9:06 A.M.

We'll see how long it takes to get there

It took us half an hour to get here

We got off exactly...

At the dam

What we need to do is cross to the other side

And the restaurant where we need to go is more or less here

The restaurant where we're going is called : LAS GAVIOTAS

I forgot to tell you before

We just came out

this is the place

there you can see the name

Food was delicious

I swear, the food it was very very good

Big portions and great price

Or to watch it with people who don't support your team

Or don't have any idea about football

I didn't film more

The game and the reactions of everyone

Because we've just met everyone there

So, I didn't know how they would feel

If it would be strange for them having a camera there

But if it's ok with them, I can film the next time

one more thing

And they gave us this

Which we'll surely put somewhere to be seen

For more infomation >> LIVERPOOL-MIDDLESBROUGH (Watching the game in Cochabamba-Bolivia)|| LA ANGOSTURA || VLOG # 40 - Duration: 14:00.

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Is there compensation for being in a clinical trial? - Penn State Health - Duration: 0:19.

Clinical trial participants are often

paid. The amount of the payment depends

on the type of activities required by

the trial, if there's travel to the site,

if there are certain activities that are

involved and the number of visits

required by the trial.

For more infomation >> Is there compensation for being in a clinical trial? - Penn State Health - Duration: 0:19.

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How do clinical trials work and what are the different phases? - Penn State Health - Duration: 1:18.

Well clinical trials are really research

studies that explore whether or not new

devices or drugs or treatment

opportunities really work in humans. It's

a very rigorous process that can take

years and years through the drug

development or device development and

that's because these studies have to

work through phases. Talk to me about the

phases. With regard to phases there

initially is a phase one and that's a

very very small subset of participants

many unhealthy volunteers and what we're

looking for in a Phase one is really

safety what's the dose of drug that we

can give that is safe. We then move on to

Phase two larger studies more people and

we're looking not just for safety but

for effectiveness as well. Then we moved

to a Phase three and that's a much

larger scale hundreds to even thousands

of participants we're looking for safety

and effectiveness and a lot of other

data. And how often do, what's the next

step as far as Phase three? Well from

phase three occasionally there are some

phase four studies but generally then

all of those truckloads of data are sent

to the Food and Drug Administration they

review all the information and then

determine whether or not the drug can go

to market.

For more infomation >> How do clinical trials work and what are the different phases? - Penn State Health - Duration: 1:18.

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How long do research studies last and what ages can participate? Penn State Health - Duration: 0:45.

Research studies vary depending on the

type of study and the study protocol but

they could be as straightforward and

simple as one single visit that might

involve answering some interview

questions or questionnaire to studies

that last many years in duration.

But participants are told right up front so

they can use that and factoring it into

their decision. And what about ages?

All research studies recruit

different participants but children

through adults can participate depending

on the study itself. And they really are

making a difference at the Medical Center.

Absolutely, it's only through engaging

people in research studies that we can

make the medical advances to help all of

us live healthier.

For more infomation >> How long do research studies last and what ages can participate? Penn State Health - Duration: 0:45.

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Citroën C1 1.0-12V Ambiance 3 DRS | Garantie | Leer | Airco | Lmv - Duration: 1:01.

For more infomation >> Citroën C1 1.0-12V Ambiance 3 DRS | Garantie | Leer | Airco | Lmv - Duration: 1:01.

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Aube Dorée : Une Affaire Personnelle - Duration: 1:30:01.

For more infomation >> Aube Dorée : Une Affaire Personnelle - Duration: 1:30:01.

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It's Foxx On Fox | Season 1 | BEAT SHAZAM - Duration: 1:40.

Beat Shazam, Beat Shazam, Beat Shazam.

All right, here we go.

Beat Shazam, hosted by me, Denzel Washington.

All right, so you're trying to beat Shazam, OK?

Heh, heh, heh, heh.

Whenever we create a show like this,

you always say to yourself, who would be the perfect host?

And the only thought was Jamie Foxx.

We're on the street.

We got money.

And we got music.

And we got everybody.

Make some noise right now.

I come from TV.

And I'm like, when is my opportunity to come back,

and how do I do it?

The idea of having a variety show, and music playing,

and trying to win money.

And then the technology of the app Shazam--

I said, wow, this is it.

One, two, three--

(SCREAMING)

We all love him as the movie star

that he is, the TV star that he is, the recording artist.

He's just a musical genius himself.

It's fun, because when you hear

your favorite song playing, what happens is, organically,

it becomes a party.

How fast can you name the song?

DIRECTOR: OK, good.

How fast?

I'm looking forward to giving out that money and staying

friends with some of these people just in case,

you know, they need to, you know, let some of that money

go.

That's what's great about the show,

that's what's great about being here, it's good old fun.

Sha-damn, if you miss Shazam.

Don't miss my new show Beat Shazam on Fox.

Sha-damn, if you miss my show Shazam.

For more infomation >> It's Foxx On Fox | Season 1 | BEAT SHAZAM - Duration: 1:40.

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Superhero Actors Who Look Nothing Like They Used To - Duration: 5:22.

For as long as Hollywood's been making movie magic, ambitious actors and actresses have

squeezed themselves into spandex hotpants, worn clunky prosthetics, and otherwise pushed

themselves to the physical limits* to portray some of our favorite superheroes.

But after shooting wrapped, not all of those stars stayed in peak crime-fighting condition.

Here are some silver-screen heroes you'd never recognize today.

Chris Evans

Don't worry, Chris Evans still looks every inch the Captain America you know and love

— but he also doesn't look anything like he did back in his first stint as a Marvel

superhero in 2005's Fantastic Four.

Most people have forgotten that Evans ever starred in that franchise, probably because

when he played the Human Torch, the actor looked less like himself and more like Chris

Evans' smaller, hairier little brother — with a regrettable haircut.

If Evans could go back in time, he'd only have one thing to say to his younger self:

"Son, just don't."

Tobey Maguire

Tobey Maguire still made a believable onscreen teenager back in 2002, when Sam Raimi finally

got his hands on the superhero franchise he'd always wanted and cast the 20-something actor

as Spider-Man.

Since then, however, the actor has experienced a lot of life changes: celebrating his 40th

birthday, becoming a father, and trading his youthful musculature for a physical condition

most famously known as "dadbod."

Liam Neeson

Before he launched the career renaissance that turned him into everyone's favorite Action

Dad, Liam Neeson starred in one of the weirdest superhero movies of the 20th century: the

1990 cult classic Darkman.

The film was the brainchild of Sam Raimi, who wanted to direct a superhero flick but

hadn't quite gotten the whole Army of Darkness aesthetic out of his system.

In Darkman, Neeson spent most of his screen time looking less like Bryan Mills and more

like a wayward extra from The Walking Dead.

Needless to say, he looks very different now: nearly 30 years older, and with, you know,

an actual face on his face.

Michael Keaton

Batman made a huge impact on moviegoers back in 1989* — with the now-65-year-old Michael

Keaton playing the man in the suit.

Because superhero standards were a bit different back then, Keaton might actually have more

muscle nowadays than he ever did as Batman, now that he's suiting up for another superhero

movie adventure.

Back then, he had to keep his weight in check in order to avoid outgrowing the unforgiving

rubber bat-suit.

"They don't make them like they used to!"

But he's definitely lost certain elements of his trademark superhero look… including

some hair.

Val Kilmer

Back in 1995, Val Kilmer followed in Keaton's footsteps to become the superhero star of

Batman Forever.

Notably, he also became the first Caped Crusader to wear the infamous nippled bat-suit...which,

let's be honest, is actually the most accurate bat-suit.

But in the 20 years since he bested the Riddler and saved Gotham City, Kilmer has definitely

not kept up with his superhero workouts… or even his hair, apparently.

Whatever Kilmer's been up to in the intervening years, it's safe to say he'll have his work

cut out for him if he wants to take his old costume out for a nostalgic spin.

Anna Paquin

Back in the beginning of Bryan Singer's X-Men franchise, Anna Paquin was a young brunette

who hadn't yet shed her teenage baby fat.

And now?

She's a grown-up blonde in her thirties with two actual babies of her own and a starring

role on HBO's True Blood.

Although she's stunning in both roles, the Anna of today is practically unrecognizable

as the girl with the deadly touch who attended Xavier's School for Gifted Youngsters.

Dolph Lundgren

Lantern-jawed, dark-haired, and oozing intimidation, back in 1989 Dolph Lundgren became the first

feature-film incarnation of Frank Castle, better known as The Punisher.

However, Lundgren's brunette locks only lasted as long as the movie did — and nearly 30

years later, he doesn't look a thing like that vengeance-obsessed anti-hero.

The big Swede has long since gone back to his original blond, which is coming in platinum

at the roots as he approaches 60.

And while he's still in terrific shape, he's morphed from a baby-faced Punisher into a

craggy, cranky member of the Expendables.

He still loves those big scary guns, though.

Alec Baldwin

Lately, this Hollywood A-lister — and sometime-presidential impersonator — sports a luxurious head of

silver hair and an age-appropriate bit of paunch around his midsection.

But he cut a lean, tall-dark-and-handsome silhouette back in 1994, when he played the

hypnotically gifted pulp hero The Shadow.

Baldwin's brief foray into superhero films saw him wearing a greasy wig and some scary

prosthetic fingernails, along with a very respectable set of crime-fighter's pecs.

Billy Zane

In the vast pantheon of superhero flicks, Billy Zane's turn as the gun-slinging, horse-wrangling,

purple-spandex-wearing star of The Phantom often goes overlooked.

But it happened, and there's no taking that back.

That was in 1996, and Zane's appearance has dramatically changed in the intervening decades.

Back then, he was in peak crime-fighting condition with a shredded, screen-ready physique, not

to mention a full head of hair.

Now, he's bald and sporting a bit more padding around his midsection — although that might

be intentional, so he can better fill out his role as the latest celebrity KFC spokes-Colonel.

Whatever the reason, more power to him.

Because you know what they say...

"Listen to your friend Billy Zane.

He's a cool dude."

Thanks for watching!

Click the Looper icon to subscribe to our YouTube channel.

Plus check out all this cool stuff we know you'll love, too!

For more infomation >> Superhero Actors Who Look Nothing Like They Used To - Duration: 5:22.

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Aube Dorée : Une Affaire Personnelle - Duration: 1:30:01.

For more infomation >> Aube Dorée : Une Affaire Personnelle - Duration: 1:30:01.

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3 Genes That Give People Superpowers - Duration: 6:08.

Who hasn't dreamed of having superpowers?

There's probably some part of you that wishes a radioactive spider or a chemical dump could

give you some epic origin story.

But it turns out, there really are somewhat-superpowered people who walk among us,

thanks to different mutations in their DNA.

Since your DNA controls everything about you, from what you look like to how your body works,

small changes in it can lead to really big changes in things like strength and speed!

Take your muscles.

There are lots of different molecules that affect how muscle tissue grows,

including your skeletal muscles—the ones you use when you move, and also look super great.

One of these molecules is a protein called myostatin, and it's put together from the

instructions in a gene known as MSTN.

Normally, myostatin binds to certain receptors on your skeletal muscle cells,

which activates signaling pathways that limit how much they grow and divide.

But researchers have found at least one mutation in the MSTN gene that creates

what's known as a loss of function.

It changes the instructions enough that the gene stops making myostatin molecules—

or at least, stops making proteins that work.

Without myostatin, your muscle cells grow bigger and divide way more than usual,

which means a huge boost in muscle mass and sometimes more strength.

And that leads to a condition called myostatin-related muscle hypertrophy, where people—even children—

can look like extra-ripped bodybuilders, but without doing any of the extra heavy-duty workouts.

And the condition doesn't seem to cause any health problems.

So scientists are researching myostatin-related therapies to treat people who have muscle

weakness or whose muscle cells die too quickly.

Now, huge muscles are one common superhero trait, but what about bursts of power and

speed like the Flash?

Well, turns out there's a mutation for that too.

There's a protein in skeletal muscles called alpha-actinin-3, which is encoded by the ACTN3 gene.

And it seems to be involved with fast-twitch muscle fibers.

Fast-twitch fibers are basically what they sound like:

they're muscle cells that have quick contraction times and give you bursts of force.

They're the muscle cells that let you sprint really fast.

And fast-twitch fibers are usually full of proteins that break down the long, sugar-storing

molecule called glycogen,

turning it into glucose and other energy-packed compounds that your muscles need to work.

Now, researchers aren't entirely sure what alpha-actinin-3 does.

But they think the protein could help with a number of things, like making or stabilizing

fast-twitch fibers or breaking down glycogen.

So, if everyone has this gene, why can't we all sprint like Usain Bolt?

Well, lots of people have a loss-of-function mutation in the ACTN3 gene, so they don't

have working alpha-actinin-3 proteins.

But it's been found that some top-notch sprinters and weightlifters have at least

one functional copy of this gene,

which means they can make the proteins that might help with seemingly-superhuman bursts

of power and speed.

But if endurance is what you're after, there are some genetic conditions that can increase

the strength of your bones.

Kind of like Wolverine's skeleton… minus the adamantium.

There's a gene called LRP5, which holds instructions for a protein with a mouthful of a name:

low density lipoprotein receptor-related protein 5.

Because it's a receptor-related protein, it's found in lots of your cell membranes,

and it's involved with chemical signaling between cells.

We know that LRP5 is part of what's known as the Wnt pathway,

a signaling pathway that affects lots of important cell processes, including cell development.

And some people have a gain-of-function mutation in LRP5,

meaning that the altered gene causes its protein to have a whole new function.

It seems this mutation can kickstart certain signaling pathways on your bone cells, making

them grow denser and bulkier—

conditions that are generally called osteosclerosis and hyperostosis.

Some people with these conditions don't have any health problems.

In fact, having extra-dense bones might mean they don't have to worry about breaking an arm

or fracturing their skull as much as the rest of us do.

But in other cases, this kind of mutation can cause too much hyperostosis, which can

lead to really severe forms of bone growth,

like where your skull puts pressure on your brain, or your bones pinch your nerves.

In any case, researchers want to study LRP5 to better understand how genetics can play

a role in bone growth,

like to understand what causes or can treat osteoporosis.

So next time you're daydreaming about superpowers while reading some X-Men comics,

keep in mind that we are all mutants in some way.

It's just that some of our mutations only affect our hair color or our tolerance for milk,

instead of giving us huge, awesome muscles.

This episode is brought to you by 23andMe, a personal genetic analysis company

created to help people understand their DNA.

The name '23andMe' comes from the fact that human DNA is organized into 23 pairs of chromosomes.

Through genetic analysis, 23andMe users can see which regions around the world their ancestors came from,

and learn how their DNA influences facial features and hair,

and sense of taste and smell, and sleep quality, and more.

Just a few weeks ago, I sent in my saliva for analysis.

Now that I have the results back, I have learned about my health, my ancestry, and my personal traits.

I've discovered that I'm 62% English Irish, but for some reason, 90% of my X Chromosome is French German!

That's weird! Also, my close DNA Relatives are 65% less likely to have skydived,

which I do not find surprising.

And I have 275 Neanderthal variants, which is less than most europeans so, basically,

I am a below average Neanderthal.

That's just a tiny glimpse, the whole report was so much fun to go through

and I feel bad I didn't get one for my wife too, so we could go through it together.

I can also learn about my predispositions to different diseases,

or choose to keep that information hidden if I would rather not know.

I can even get in touch with 23AndMe users who share my ancestry.

If you want to do the same—and also support SciShow—

it's super fun, and you can check out 23andMe.com/SciShow.

For more infomation >> 3 Genes That Give People Superpowers - Duration: 6:08.

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MOROCCAN TAG DARIJA SOUS-TITRÉ l HindaToTheWorld - Duration: 17:20.

For more infomation >> MOROCCAN TAG DARIJA SOUS-TITRÉ l HindaToTheWorld - Duration: 17:20.

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Ed Sheeran - Happier [COVER] | Harrison Frone - Duration: 3:14.

Walking down 29th and Park I saw you in another's arms

Only a month we've been apart You look happier

Saw you walk inside a bar He said something to make you laugh

I saw that both your smiles were twice as wide as ours

Yeah, you look happier, you do

Ain't nobody hurt you like I hurt you But ain't nobody love you like I do

Promise that I will not take it personal, baby

If you're moving on with someone new

'Cause baby you look happier, you do My friends told me one day I'll feel it too

And until then I'll smile to hide the truth But I know I was happier with you

Walking down 29th and Park I saw you in another's arms

Only a month we've been apart You look happier

Saw you walk inside a bar He said something to make you laugh

I saw that both your smiles were twice as wide as ours

Yeah, you look happier, you do

Ain't nobody hurt you like I hurt you But ain't nobody love you like I do

Promise that I will not take it personal, baby

If you're moving on with someone new

'Cause baby you look happier, you do My friends told me one day I'll feel it too

And until then I'll smile to hide the truth But I know I was happier with you

'Cause baby you look happier, you do My friends told me one day I'll feel it too

And until then I'll smile to hide the truth But I know I was happier with you

For more infomation >> Ed Sheeran - Happier [COVER] | Harrison Frone - Duration: 3:14.

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Skin Whitening Forever Review – Does it Work? Let's See How Amazing It Works For You - Duration: 3:15.

Skin Whitening Forever Review – Does it Work? Let's See How Amazing It Works For You

For more infomation >> Skin Whitening Forever Review – Does it Work? Let's See How Amazing It Works For You - Duration: 3:15.

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Surfing World Games: Cherif Fall Sénégal - Euskadi Surf TV - Duration: 0:56.

For more infomation >> Surfing World Games: Cherif Fall Sénégal - Euskadi Surf TV - Duration: 0:56.

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What is "smart reply" in the "Inbox" and "Google Allo" - Duration: 2:11.

What is "smart reply" in the "Inbox" and "Google Allo"

Hello everyone

This time, we will discuss "Inbox" and instant reply function has been installed in the "Google Allo" "smart reply"

"Smart reply" is a feature that will display the correct reply candidate for the received message,

It has become to be able to reply quickly message by selecting from among the

The first is mounted on the "Inbox", but has become available then even been released "Google Allo",

Even "Gmail" from May 2017 now available

However, "smart reply" For now English only does not support, have decided support of the Spanish but also in the most recent, Japanese support is undecided at the moment

Therefore the opportunity to take advantage of current situation, but I think not much, I think I may have been put in a corner of the head towards the future of Japanese support

"Smart reply" will be displayed reply candidates three against the received message

If you touch any from among them, the reply screen of a state in which the selected text has been entered is displayed on the direct,

Or sent as it is, or you can send adds a text

That is why Habukeru the trouble of entering the character even a little

The "smart reply" is because it is also equipped with AI function, learning the words that the user frequently used in the reply,

It will become to be able to select the most likely to use in the reply words as "smart reply"

"Smart reply" For now the corresponding leverage scene in Japan because the language is limited is quite small but, let's remember for the future of Japanese support

Above, it was the explanation for the "Inbox" and instant reply function has been installed in the "Google Allo" "smart reply"

For more infomation >> What is "smart reply" in the "Inbox" and "Google Allo" - Duration: 2:11.

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What is Personalized Medicine and how is it used? Penn State Health - Duration: 1:59.

Personalized medicine is the process by

which we understand an individual's

genetic makeup in a way that allows us

to help predict the person's

susceptibility to disease or decide what

would be the optimum treatment for that

individual. The Institute for

Personalized Medicine opened it's doors

four years ago. About 30 different

clinical areas at the Medical Center

work with the Institute to provide more

precise care. Here's how it works

with patients. The oncologist will first

determine whether or not they have

cancer and if so, one of the first things

that they will do is take a sample of

that tumor, extract the DNA, send it off

to a company to have them determine the

genetic changes that have occurred and

on the basis that information integrate

that into the choice of therapeutic

treatments. So patients receive

personalized treatment. We don't treat

all breast cancers the same. We do an

analysis of the genetic changes that

have occurred in that particular tumor

and on the basis of that we can

prescribe different therapeutic regimens

and this has been extremely effective

particularly in the targeted therapies

that have been developed in conjunction

with genotyping over the last five years

of being able to have a remarkable

effectiveness in reversing the effects

of the cancer. And that's Dr. Claxton's

goal for his patients. I think that what

we're doing is going to change the way

other people elsewhere do this sort of

work. I think it's ultimately going to

find its way into day to day routine

leukemia evaluation and treatment.

I think that what we're doing here is very

innovative. We feel it's absolutely

essential for the future.

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