cholesterol lowering drug doesn't risk your memory.
A recent study has found that in patients on statin therapy, the addition of a cholesterol-slashing
drug did not impair brain function.
A new class of cholesterol lowering drugs, PCSK9 inhibitors, effectively lower LDL cholesterol
levels beyond current treatment targets and new research showed that these lower levels
result in a reduction in adverse cardiovascular events, making these drugs attractive treatment
options for patients who do not achieve their target cholesterol level with statin therapy
alone.
However, previous research had raised the possibility that a low level of LDL cholesterol
and/or use of statins may negatively impact memory and overall cognition.
New research led by the TIMI Study Group at Brigham and Women's Hospital in collaboration
with Brown University and the University of Geneva reassuringly finds no association between
the use of the PCSK9 inhibitor evolocumab and a decline in memory or cognitive function.
After an average of 19 months of treatment, our data show that changes in memory and cognitive
function were very small and similar between patients treated with evolocumab and those
treated with placebo," said senior investigator Robert Giugliano.
"These data should reassure physicians and patients who may have had questions about
the safety of this drug as it pertains to cognitive impairment."
"We examined tests of potential adverse effects of the treatment on not only memory
but also attention and reaction time that are important aspects of cognition that could
seriously impact daily functioning," said researcher Brian R. Ott.
"We found no significant differences during the course of the study between the active
and placebo treatment groups for any of these cognitive domains.
Results of cognitive testing also did not vary by the achieved level of low-density
(bad) cholesterol, including the group who were treated with evolocumab and achieved
low-density cholesterol below 25 mg/dL, a level that is far below current treatment
goals.
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