I'll show you how to
make these bath bombs they are so
beautiful, delicate I'm in love with them
and I'm sure you
You'll be as well! So let's start?
The first thing I'm going to show
It is the mold that I am using
I do not have the ideal mold ... but I
had a ball it was my
dog's
I cut it in half with the bread knife
It's easy, it's not difficult to cut! I had 2 balls
This one is a rubber ball that I also cut it
in half this one is smaller
I wanted a smaller size also
You can find the molds on the Internet but
I have not bought it, so I'll
use these balls!
In a separate pot add the
dry ingredients... and another add the liquid ones
You will need a strainer
Strain all the dry ingredients here
1cup baking powder is good to strain these ingredients to undo the pieces ....
1/2 cup Epsom salt
you will find it in pharmacies or on the
Internet
It has some pieces then try to undo it. The epsom salt is very good because it helps to relax the muscles
It takes away the cramps. Then I'll make a special post on Blog talking about Epsom Salt and will let you know so
you can read more about the benefits of it!
1/2 cup citric acid
It has to be
Citric acid because it's cheaper
you will also be able to find it on
the Internet, but not sure if you can find it in pharmacies!
Use a spoon or spatula just to
mix everything!
now we will mix
the liquid ingredients
In a small bowl Place 3 tablespoons of tap water
Add
essence am using an lavender essence
I'm using
about 30 drops of essence
if you want to add (I think It's very interesting)
1 tablespoon
coconut oil because you know
I am a fan of coconut oil and it is too good for the skin and for
your health too ... I'm using this
organic oil .. I'll put here
Also add the food color
This mix yields3 recipes of the dry ingredients
Because you can not put too much of the liquid in the salt mixture
I'll show you later why
if you have a fuet you can
mix ... now
add this mixture little by little, because if you put enough
will effervesce it all
Mix well and add 1 spoon
this is NOT what you want to happen :)
I prefer to mix it with my hand
You can not put too much! I'll do the test
here to see if it has already
if it gets too dry it will not
stick together
if it's not sticking it is
because it has little liquid so put it back again! So
add a little bit of liquid!
so let's put one more
spoon we will mixing
It's better to add less then too much liquid
This is how we want it to be! So let's tighten it! Add enough salt in the mold
now we will squeeze them together
Leave a little while in the pan
fills the other one. Beat with a spoon ... and remove the mold with
carefully
Remove excess with a knife
now will take the big one you will
see also look how beautiful it is !!!
Very beautiful! I loved!!!
How beautiful!!!!
Beat with spoon this side also
For me these balls were perfect as molds
then will be for you too!
looks beautiful
This is the first recipe I made
here I added too much liquid
Its shape was a ball after a few minutes it turned into a
"bread", but
all right, we learn!
You can do two-tone! Place on paper towels to dry!
Now SHOW TIME !!!!
Thanks for watching another video! if you liked
this video give a THUMBS UP
Subscribe to the channel and stay tuned for more
news here and at the BLOG ok?
a big kiss for you and until next !!!
For more infomation >> Esferas Efervescentes Para Banho-Bath Bomb Recipe E 56 - Duration: 6:48.-------------------------------------------
Most Dangerous Stunt In The World - Just For Entertainment - Must Watch !! - Duration: 3:04.
Most Dangerous Stunt In The World - Just For Entertainment - Must Watch !!
Hi guys in this youtube video i will perform and teach you the most dangerous stunt in
the world.
Don`t try this at home as i have done this under expert supervision
and taking every kind of safety measures.
LOL!!
This is just for entertainment guys
and i do not have any intentions of offending anyone or hurting anyone`s emotions.
Again this is just for laughs and just for entertainment.
Chill and enjoy.
Hit thumbs up if you liked it, subscribe if you loved it, this is prajwal from technology
gym, signing off, goodbye.
Most Dangerous Stunt In The World - Just For Entertainment - Must Watch !!
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stunts | prank | world's most dangerous stunts
-------------------------------------------
Fishing Puyaw On river Karang Mumus Samarinda - Fishing Mania Top - Duration: 10:40.
Meet again with the team MMG Kaltim
Now we are on the banks of the river upstream of Karang Mumus that divides the city of Samarinda
This location belida there are many fish, belida, tarpon, tilapia, puyaw, etc.
Now we've arrived at the spot
This time our target fish is a fish puyaw or melem that many inhabit this river
Here we shall attempting fishing puyaw
Once throwing, strikeee, indeed spot steady
Fishing a few hours for the result passable
The size varies from 2 to 5 fingers
Steady
Seeing friends so engrossed pull puyaw I was interested to try
But first I will make a series of eye kailnya
Circuit for fishing puyaw we use a series of regular heavy foundation
with a hook to the size of the number 2
And the bait we use is sliced raw tempe
Take soy beans and then cut into 2
Now we are ready to fish puyaw
Fish puyaw or glue is a freshwater fish
Many are found in rivers and lakes
Puyaw fish shape similar to goldfish
There is a faint black mark tail section
Color to silver-white scales silvery
Memeliki sengot and a small mouth
Up here our first fishing adventure
Meet again in the next fishing trip
Regards.
-------------------------------------------
The LEGO Batman Movie
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Love Ciara?
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Pierwszy odcinegg = Gameplay TFM (Tak pięknie zmontowany x'D) - Duration: 9:03.
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Kia pro_cee'd pro_cee`d 1.6 GT Navigatie/Leder - Duration: 1:10.
-------------------------------------------
MINI Countryman 1.6 ONE D CHILI NAV - Duration: 0:54.
-------------------------------------------
Synchronising education with adolescent biology - Duration: 4:34.
-------------------------------------------
Présentation du Trofinetide par Neuren Pharmaceuticals (sous-titres FR) - Duration: 10:09.
Introduction to Neuren.
Neuren Pharmaceuticals is a biopharmaceutical
company, developing new medicines for
diseases and disorders of the central
nervous system or "CNS".
We have four ongoing clinical development programs
on acute conditions : traumatic brain injury
and concussion, and chronic disorders :
Rett syndrome and Fragile X syndrome,
as well as preclinical R&D programs
in a range of other CNS conditions.
Our expert team in Australia,
the US and the UK, includes people with
many years of experience in all aspects of
pharmaceutical development and commercialization.
Neuren shares are traded on the Australian Securities Exchange,
under the code NEU.
What is Trofinetide ?
Trofinetide is the name proposed by the
World Health Organization for our lead
clinical-stage drug candidate.
It is an analog of a molecule, which is derived
from IGF-1 and occurs naturally in the brain.
IGF-1 is a growth factor
stimulated by growth hormone.
In the central nervous system, IGF-1 is produced
by both of the major types of brain
cells : neurons and glia.
IGF-1 in the brain is critical, both
for neural development and for responding
to injury and disease.
In the brain, IGF-1 gets broken down in two separate
molecules : one often referred to as
glypromate - or GPE - comprises the last
three peptides of IGF-1.
GPE affects glial cells, astrocytes and microglia,
while IGF-1 itself mostly affects neurons.
One of the effects of GPE is that
it actually increases production of IGF-1
by neurons and glial cells.
Trofinetide is Neuren's chemically modified
form of GPE, that can mimic GPE's natural
function in the brain.
The small modification results in the drug having
an increased half-life in the circulation,
better stability for easier storage and shipping,
and suitability for use as an oral medication,
whereas GPE itself and
IGF-1 can only be administered by injection.
In the brain, the role of IGF-1 and GPE
is to facilitate the brain's development
and maintain the biological balance
required for normal functioning.
These processes have evolved over millions of years
and are still being extensively
researched by scientists.
During development, the brain and the cells that
make it up change rapidly and in complex ways.
IGF-1 and GPE play a significant
role in regulating these changes.
In the mature brain, IGF-1 and GPE play
an equally important role in responding
to disease, stress and injury.
Whereas most drugs typically exert a
specific effect on a specific target,
Trofinetide exerts diverse effects which
can help to control or normalize
abnormal biological processes in the brain.
Common Pathology Among CNS Disorders
All the different CNS conditions, brain injury,
neurodevelopmental disorders and
neurodegenerative diseases can result in
very different symptoms and outcomes,
many share common underlying
pathological features.
These include : inflammation, overactivation of microglia
(a type of glial cell),
dysfunction of synapses
(the connections between neurons
through which information is transmitted)
and reduced levels of IGF-1.
In other words, diseases and conditions caused by
different mechanisms often result in the
same pathology, at the cellular and
molecular level.
Let's look at these four features.
Inflammation.
Inflammation in the brain,
often referred to as neuroinflammation,
is perhaps the most common pathological
feature of CNS disorders.
Much of it is the result of excess production of
molecules called inflammatory cytokines.
These are prominent in brain injuries,
neurodevelopmental disorders such as
Rett and Fragile X syndromes, as well as
autism, neurodegenerative diseases like
Alzheimer's and Parkinson's and even
so-called normal aging.
Neuroinflammation places significant stress on brain cells.
Stress can disrupt normal cellular processes,
such as information signaling,
increase energy requirements beyond the
ability of the cells to meet their
metabolic needs,
disturb electrical functions which can lead to seizures
and other abnormalities, and even result in
premature cell death.
In animal models, ranging from brain injury and stroke
to Fragile X syndrome to age-associated
cognitive impairment, Trotinetide has
showed an ability to significantly reduce
the levels of inflammatory cytokines.
This has resulted in an improvement in a wide
range of symptoms including
post-traumatic seizures, anxiety,
memory impairment and hyperactivity.
Microglial activation.
Microglia are the resident immune cells in the brain.
Once thought to serve primarily a
sentinel function, responding to
infection and damaged cells by
surrounding and removing them from the
CNS, it is now known that they play a
central role in maintaining synapses
during development and in mature brains
by pruning dendrites (the many small
extensions of neurons that form synapses).
Microglia are also a key source of IGF-1.
Due to this wide-ranging maintenance function,
they have appropriately been
referred to as the "constant gardeners" of
the brain.
Microglia are not only activated in response to
infection and injury.
They are also activated by
inflammation that accompanies acute
brain injury and chronic CNS conditions.
In this activated state, they not only
lose their ability to effectively
perform their normal function in
synaptic maintenance, but also produce
more inflammatory cytokines which can
further compound and damage neurons
and other brain cells.
Trofinetide has been shown to normalize microglial biology
and function, in both acute and chronic conditions.
Restoring normal microglial activity has resulted in
improved synaptic structure as well as correction
of imbalance and synaptic signaling and
cell-to-cell communication.
This has led to reversal of symptoms such as
impaired memory, anxiety, hyperactivity and
compromised social behavior.
Synaptic dysfunction.
Neurons communicate with each other by chemical and
electrical signals transmitted via synapses.
Normal synaptic function is essential for healthy brain function
and underlies memory, cognition, behavior
and other brain activities.
Normal synaptic function requires that
the dendrites (part of the neurons which
form synapses) are appropriately formed
as well as that excitatory and
inhibitory signals are kept in balance.
When dendritic structure and synaptic
signaling are abnormal, virtually all
brain activities can be negatively impacted.
Synaptic dysfunction is then
identified as a core feature of many CNS conditions,
including acute brain injury,
neurodevelopmental disorders and
neurodegenerative diseases.
For example, in Rett syndrome,
dendrites are sparse and immature,
while in Fragile X syndrome,
dendritic branching is excessive
although the dendrites are also immature.
Trofinetide increases the length
and branching of dendrites
in the model of Rett syndrome
while increasing pruning of
excess branching in Fragile X syndrome.
In the Fragile X animal model, aberrant
synaptic signaling was normalized within
15 minutes of the first dose.
IGF-1 dysregulation.
As previously mentioned,
IGF-1 levels in the brain have been
reported to be depressed in a number of
CNS conditions, particularly in Rett and
Fragile X syndromes and brain injury.
In these conditions, the critical role of
IGF-1 and GPE in maintaining and
repairing brain cells and synapses is impaired.
In the Fragile X model, in which
the IGF-1 level is depressed,
Trofinetide increases the amount of IGF-1 to
normal levels.
This was accompanied by normalized synaptic signaling
and complete reversal of cognitive and
behavior abnormalities.
In the model of Rett syndrome,
increasing IGF 1-levels has been
reported to correct deficits in dendritic spines,
and in isolated cells
from human Rett syndrome patients, both
IGF-1 and GPE are able to partially
reverse the deficits in cellular function.
Summarizing, Trofinetide helps to
correct four of the hallmark pathological
features of many CNS disorders :
inflammation, abnormal microglial function,
impared synaptic signaling and
disrupted IGF-1 expression.
By simultaneously targeting multiple
processes, Trofinetide works to restore
the natural balance of brain function.
For more information, please visit our website.
-------------------------------------------
Happy new year :3 - Duration: 0:31.
I hope you have a happy new year :3
-------------------------------------------
Top 10 Toy Story Facts! - Duration: 2:15.
Hello how are you guys doing today my name is black tarzan and today we are going to
be going over the top 10 facts about toy story!
Coming up!
In their most productive week during production, Pixar completed 3.5 minutes of animation.
Tim Allen and Pixar originally wanted Jim Carrey to voice Buzz Lightyear, but they couldn't
due to the low budget they were given for the film.
The movie was originally supposed to be called "You Are A Toy."
Buzz Lightyear's original name was Lunar Larry.
Hasbro denied Pixar the use of the name GI Joe when it was informed that a GI Joe doll
was going to be blown up by Sid.
Pixar used army men instead.
The number "95" appears frequently throughout all 3 films.
This is in reference to the year the original Toy Story was released, 1995.
Toy Story 2 was initially planned as an hour long sequel that would have premiered on home
video.
Toy Story 3 is the first sequel to be nominated for the Best Picture Oscar without any of
its predecessors being nominated.
Toy Story 3 is also the first animated movie to make over $1 billion at the box office
worldwide.
It's the #5 highest grossing movie of all-time.
Toy Story was completed on a $30 million budget using a staff of 110.
In comparison, The Lion King, released in 1994, required a budget of $45 million and
a staff of 800.
Be Sure to subscribe to my youtube channel!
Hit that red subscribe button to become a member of the black tarzan channel today!
My name is black tarzan!
Thank you so much for watching I really appreciate it!
-------------------------------------------
Fishing Puyaw On river Karang Mumus Samarinda - Fishing Mania Top - Duration: 10:40.
Meet again with the team MMG Kaltim
Now we are on the banks of the river upstream of Karang Mumus that divides the city of Samarinda
This location belida there are many fish, belida, tarpon, tilapia, puyaw, etc.
Now we've arrived at the spot
This time our target fish is a fish puyaw or melem that many inhabit this river
Here we shall attempting fishing puyaw
Once throwing, strikeee, indeed spot steady
Fishing a few hours for the result passable
The size varies from 2 to 5 fingers
Steady
Seeing friends so engrossed pull puyaw I was interested to try
But first I will make a series of eye kailnya
Circuit for fishing puyaw we use a series of regular heavy foundation
with a hook to the size of the number 2
And the bait we use is sliced raw tempe
Take soy beans and then cut into 2
Now we are ready to fish puyaw
Fish puyaw or glue is a freshwater fish
Many are found in rivers and lakes
Puyaw fish shape similar to goldfish
There is a faint black mark tail section
Color to silver-white scales silvery
Memeliki sengot and a small mouth
Up here our first fishing adventure
Meet again in the next fishing trip
Regards.
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