Type 2 diabetes is on the rise in the UK and if left untreated can lead to serious health
consequences such as heart disease and kidney failure.
In the advanced form of type 2 diabetes insulin release from a subset of
cells in the pancreas called beta cells is decreased
This decrease in insulin leads to an increase in circulating glucose
which itself can be toxic to the body.
Insulin release can be modulated by a subset of proteins called G protein-coupled receptors
G protein-coupled receptors are attractive drug targets because they're expressed on
the surface of the cells so therefore easily accessible.
Our lab is interested in one particular G protein-coupled receptor namely GPR75.
We've shown that GPR75 is expressed on human beta cells.
We've been investigating whether GPR75 has a role in insulin release; whether GPR75 amount
is increased with diabetes and investigating compounds that might interact with GPR75.
We believe investigating GPR75 will increase out understanding of type 2 diabetes and that
GPR75 itself may be a novel drug target for the disease.
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