Wednesday, February 28, 2018

Youtube daily report Feb 28 2018

We just got the first teaser trailer for Wreck-It Ralph 2 and hidden in there are some sneaky

Disney easter eggs including Aladdin's lamp, Star Wars favourites Yoda and Chewbacca, plus

our first look at Ralph breaking the internet.

Yippee-ki-yay, movie lovers, it's Jan here and this is my Wreck-It Ralph 2 trailer breakdown

for all the Disney and movie references you might have missed.

Don't forget to let me know about any other cool details you spotted in the comments below.

Thanks to footage shown at D23 last year, we already know that the Wreck-It Ralph sequel

is going to feature loads of characters from other big Disney properties, one of which

is Lucasfilm's Star Wars.

In fact, the D23 clip showed C-3PO and a bunch of Stormtroopers, along with X-wings and TIE

fighters, all appearing in a sequence that also included Disney's princesses, Dumbo,

and Iron Man!

Now, while we don't get to see those particular Star Wars figures in the new trailer for Ralph

Breaks the Internet, there is a hidden hat-tip to the galaxy far, far away in Mr Litwak's

office where, if you look closely at his shelves, you'll see a couple of decorative plates featuring

none other than the little green Jedi Master Yoda and Wookie co-pilot Chewbacca!

If you want to catch some other nice nods to Disney movies, then check out the items

on sale in the background while Ralph and Vanellope are staring at that cat painting

on eBay.

There's a Magic Lamp like the one that appears in Disney's 1992 animated musical Aladdin,

which is getting a live-action remake next year with Will Smith starring as Genie.

And there's also a Cast-Iron Frying Pan like the one featured in Disney's animated movie

Tangled.

Although its eBay listing only says that the pan is 'great for everything from frying chicken

to grilling a tortilla', it can also make a very effective weapon, as Rapunzel, Flynn,

and the Royal Guard all show very well during the course of Tangled.

"Oh, mama, I have got to get me one of these!"

When the arcade owner Mr Litwak uses his computer, you can spot a reference back to the first

Wreck-It Ralph movie.

Take a look at the bottom right side of the screen and you'll find a document called "Letter

to Nana".

In the first film, Litwak mentions his senile nana several times:

"Mr. Litwak!"

"What's the trouble, sweetheart?"

"Oh, boy!"

"Look's like the game's gone cuckoo, like my nana!"

"I'll have someone look at it in the morning, but if he can't fix it, it may be time to

put old Ralph and Felix out to pasture.

Like my nana!"

"Sorry, sweetie.

Here's your quarter back."

"But what about the game?"

"I'll have someone look at it tomorrow..."

"But if he can't fix it, it might be time to put old Ralph and Felix out to pasture."

"Like my nana."

The final pancake scene of Ralph feeding a poor bunny so much it explodes seems like

a tease of Ralph doing what the movie's title says: breaking the internet.

The little girl who was playing the pancake-milkshake game until Ralph took over was certainly horrified

when she saw the bunny explode!

"Eat, eat!"

"Er, Ralph, you might wanna try feeding the kitty for a little while."

"No!

The kitty gets the milkshake."

"The bunny gets the pancake."

"Eeehhhh" This scene also reminded me of similar moments

in the Willy Wonka and Monty Python movies.

In Willy Wonka and the Chocolate Factory, Violet Beauregarde blows up like a giant blueberry

after she takes Willy Wonka's experimental 3-course dinner gum.

And the Wreck-It Ralph scene is also a call-back to Mr Creosote, the glutton from Monty Python's

The Meaning of Life, who explodes after he finishes an enormous meal with an after-dinner

mint.

By the way, the little girl who Ralph traumatises reminds me of Baby Moana from Disney's last

animated movie.

And it might be a way of including a Moana easter egg to repay the Wreck-It Ralph easter

egg that appeared in Moana.

The older Moana will also be appearing in a separate scene in Wreck-It Ralph 2 together

with a group of other Disney princesses.

Although we didn't get to see them in this teaser, hopefully they'll be in the next full

trailer.

There's obviously going to be a ton of pop culture references and online jokes in Wreck-It

Ralph 2.

A couple that pop up in this trailer are fake prize scams and clickbait articles.

"Congratulations, you're a winner!"

"Really?"

"These 10 child stars went to prison!"

"Ooh."

"Number six will amaze you!"

"That sounds interesting."

Now, there's a good number of actors who've ended up in jail, but I wonder if this could

be a jab at former Disney child star Lindsay Lohan who's well-known for getting into trouble

with the law and has served time.

As a child, Lohan starred in Disney films such as The Parent Trap and some of the studio's

TV movies, and, just last year, she suggested on Instagram that she should play Ariel in

a live-action version of Disney's The Little Mermaid.

Of course, given that Ralph and Vanellope are exploring the internet, there's also bound

to be some more adult-themed jokes in the movie.

I did notice that in the internet reception hall, there's an IP Address Lookup area with

signs pointing to, among other things, "Unzip Services" and browser "History Clearance".

And you can make what you want to of that!

Oh, and by the way, is that a little Mulan easter egg hiding up there as well?

Just before I finish, I want to note that we don't know a lot from this teaser about

what's going on back at the video arcade.

From the brief shots of a very empty parking lot, and the way things are lit inside the

arcade, plus the fact that Game Central Station doesn't look very busy, there's a sense that

the amusement arcade might be losing business perhaps due to online competition.

And a brief synopsis of the movie indicates that Ralph and Vanellope have ventured online

to look for a replacement part for her game Sugar Rush.

So, let me know if you've got any theories about what else you think might be going on.

So, what did you think of the teaser trailer for Wreck-It Ralph 2?

And do you feel it looks as good as the first film?

Let me know your thoughts in the comments below and if you love animation, check out

my recent Pixar videos on Incredibles 2 and Coco by tapping the screen right here.

And if you enjoyed this, don't forget to like, share and subscribe to get all my new videos!

Thanks for watching and see ya next time!

Yippee-ki-yay, movie lovers!

For more infomation >> WRECK-IT RALPH 2 Trailer Easter Eggs, Breakdown & Things You Missed - Ralph Breaks The Internet - Duration: 5:53.

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How to Make Birthday Cake Marshmallows | Easy Marshmallows Recipe | RECIPE - Duration: 3:25.

For more infomation >> How to Make Birthday Cake Marshmallows | Easy Marshmallows Recipe | RECIPE - Duration: 3:25.

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Kia Sportage 1.6 GDI X-ECUTIVE PLUS PACK / NAVI / AIRCO-ECC / HALF LEDER / CRUISE CTR. / LMV 18" / P - Duration: 1:00.

For more infomation >> Kia Sportage 1.6 GDI X-ECUTIVE PLUS PACK / NAVI / AIRCO-ECC / HALF LEDER / CRUISE CTR. / LMV 18" / P - Duration: 1:00.

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DEFEATING GRAVITY ONCE AND FOR ALL | Dark Souls | Live Stream - Duration: 2:05:16.

For more infomation >> DEFEATING GRAVITY ONCE AND FOR ALL | Dark Souls | Live Stream - Duration: 2:05:16.

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Opel Grandland X 1.2 Turbo 130pk S&S INNOVATION **LEER,NAVI.LED** - Duration: 0:59.

For more infomation >> Opel Grandland X 1.2 Turbo 130pk S&S INNOVATION **LEER,NAVI.LED** - Duration: 0:59.

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DIY Slide Wire Canopy Kit

For more infomation >> DIY Slide Wire Canopy Kit

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44XX Garfield Ave S - Duration: 17:22.

For more infomation >> 44XX Garfield Ave S - Duration: 17:22.

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Audi A6 3.0TDI 245pk S-Line Quattro Xenon Camera Navi 19" Adaptive.Cruise Keyless Pdc Pro Line Plus - Duration: 0:54.

For more infomation >> Audi A6 3.0TDI 245pk S-Line Quattro Xenon Camera Navi 19" Adaptive.Cruise Keyless Pdc Pro Line Plus - Duration: 0:54.

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Online Community feedback about the popular Parcel Lockers - Duration: 1:20.

For more infomation >> Online Community feedback about the popular Parcel Lockers - Duration: 1:20.

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Our Small Business Team responds to Online Community feedback about parcels - Duration: 2:14.

For more infomation >> Our Small Business Team responds to Online Community feedback about parcels - Duration: 2:14.

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Psalmen 50 - Duration: 2:21.

For more infomation >> Psalmen 50 - Duration: 2:21.

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what's on my playlist !! - Duration: 4:20.

*awkward whip*

take your time karis, it's fine

thats what you get

when goldfish are more important than anything you're doing

someone stop her

please

what is she doing

when you have to be your own backup singer

sure it is

*deuces*

why

why

that was embarassing

which you probably did

For more infomation >> what's on my playlist !! - Duration: 4:20.

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Auffällige Folierung, Breitbau-Kit, Chiptuning - Duration: 1:37.

For more infomation >> Auffällige Folierung, Breitbau-Kit, Chiptuning - Duration: 1:37.

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CASEY CAGLE - WikiVidi Documentary - Duration: 7:22.

For more infomation >> CASEY CAGLE - WikiVidi Documentary - Duration: 7:22.

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Kay Carlson Diary of a Legal Drug Dealer Interview Part 1 - Duration: 14:52.

For more infomation >> Kay Carlson Diary of a Legal Drug Dealer Interview Part 1 - Duration: 14:52.

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MRS. MINIVER - WikiVidi Documentary - Duration: 7:36.

For more infomation >> MRS. MINIVER - WikiVidi Documentary - Duration: 7:36.

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Funny Ice Cream Shop Play, chocolate, melon,learn color,toy, RIWORLD - Duration: 4:51.

Here it is

I am RIWON~

Ice cream

So sweet Ice cream

Hello~

Oh little princess

What kind of ice cream do you want?

I like chocolate

Here you are

Thank you very much

How much is it?

1 dollar

Here you are

Thank you

So delicious

Ice cream

Ice cream

So sweet ice cream

Hello

Hello little princess

I like melon

Here you are

Thank you

How much is it?

1 dollar

Here you are

Thank you

So delicious

Ice cream

So sweet ice cream

Hello

Hello little princess

What kind of taste do you want?

I like strawberry

Here it is

Thank you

How much is it?

1 dollar

Here you are

Thank you

So delicious

So delicious

Oh ! The ice cream ended up on the floor.

I need to clean up

So delicious

I got it on my clothes.

I am so pretty

For more infomation >> Funny Ice Cream Shop Play, chocolate, melon,learn color,toy, RIWORLD - Duration: 4:51.

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Black Shadow 6000 Irish Coffee Pack Unboxing - Duration: 1:35.

Hey guys, this is Ace here, also known as Potato Senpai

Here for another unboxing on these Saucony Grid-

Shadow-

Oh sorry um

um Shadow 9000's

Oh 6000's sorry

So, you've got the box

So you've got your size 13, it's pada the.. Coffee Pack

(licks lips)

So here we go

So we've got our deadstock receipt

Not gonna show you how much it is

(people complaining)

Alright

Oooh...

(deeply inhales new shoe aroma)

(fans scent into nostrils)

Smells like coffee

Coffee man! Can you not see the resemblance?

It's amazing

*no resemblance*

*no resemblance* Gadayum

So, we've got the nice buttery suede

Pretty excellent and the

6000 sh-ss-sh he she uhh winning sole unit

I must say these are pretty cozy

I do own a few pairs of these already

That's the right pair (rustling)

(rustling)

Also got...

the left pair!

(aaAaahhhh)

These, I must say, are pretty clean

So I got these about um

$180 AUD

$180 AUD plus tax

Picked it up from Platypus

So um lucky they had my size

um size 13 US

and um, yeah!

um

I would definitely recommend

Alright guys, see you next time

That's on Solebox Unit

I'm Potato Senpai, also known as Ace!

See you again

See you again (salutes)

For more infomation >> Black Shadow 6000 Irish Coffee Pack Unboxing - Duration: 1:35.

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The most dangerous drone in world so for - Duration: 4:18.

The General Atomics MQ-9 Reaper (sometimes called Predator B) is an unmanned aerial vehicle

(UAV) capable of remotely controlled or autonomous flight operations, developed by General Atomics

Aeronautical Systems (GA-ASI) primarily for the United States Air Force (USAF).

The Reaper has a 950-shaft-horsepower (712 kW) turboprop engine.

The aircraft is monitored and controlled by aircrew in the Ground Control Station (GCS),

including weapons employment.

The Reaper is also used by the United States Navy, the CIA, U.S. Customs and Border Protection,

NASA, and the militaries of several other countries.

For more infomation >> The most dangerous drone in world so for - Duration: 4:18.

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Big Gummy Vs. Lil Gummy

For more infomation >> Big Gummy Vs. Lil Gummy

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Francis D. Pastorius Elementary Celebrates Black History Month - Duration: 0:31.

For more infomation >> Francis D. Pastorius Elementary Celebrates Black History Month - Duration: 0:31.

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Volvo S80 2.0D Limited Edition - Duration: 0:54.

For more infomation >> Volvo S80 2.0D Limited Edition - Duration: 0:54.

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Online Community feedback about the popular Parcel Lockers - Duration: 1:20.

For more infomation >> Online Community feedback about the popular Parcel Lockers - Duration: 1:20.

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Isola: Eva e Francesco erano d'accordo? Retroscena bomba sulla droga - Duration: 4:23.

For more infomation >> Isola: Eva e Francesco erano d'accordo? Retroscena bomba sulla droga - Duration: 4:23.

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Desert Island Plugins Ep.1 - Lounge Lizard - Duration: 18:21.

I know I spelled "totally" wrong.

That's hardly the biggest mistake in the video...

For more infomation >> Desert Island Plugins Ep.1 - Lounge Lizard - Duration: 18:21.

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Kay Carlson Diary of a Legal Drug Dealer Interview Part 1 - Duration: 14:52.

For more infomation >> Kay Carlson Diary of a Legal Drug Dealer Interview Part 1 - Duration: 14:52.

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Diagnostic Testing Algorithms for Celiac Disease [Hot Topic] - Duration: 18:33.

Hi, I'm Matt Binnicker, the Director of Clinical Virology and Vice Chair of Practice

in the Department of Laboratory Medicine and Pathology at Mayo Clinic.

Celiac disease is an inherited, autoimmune disorder that affects the digestive process

of the small intestine.

And did you know that it's estimated that 1% of the U.S. population, or about 3 million

people, are living with this disease?

Well, because of its significance, it's important that we understand the clinical

manifestations of Celiac disease, as well as how to test for it.

In this month's Hot Topic, my colleague, Dr. Melissa Snyder, will review the diagnostic

testing algorithms for celiac disease, and highlight the advantages and limitations of

certain tests, including serology and genetic assays.

I hope you enjoy this month's Hot Topic, and I want to personally thank you for allowing

Mayo Clinic the opportunity to be a partner in your patients' healthcare.

Thank you, Dr. Binnicker.

Hello, Everyone.

My name is Melissa Snyder, and I am the Co-Director of the Antibody Immunology Laboratory at Mayo

Clinic in Rochester, Minnesota.

I'm so glad you are able to join me for a brief discussion about celiac disease and

the role of diagnostic testing algorithms.

Before beginning the presentation, I have one disclosure to make.

I have served as a member of the Strategic Advisory Committee for Inova Diagnostics,

which is an in vitro diagnostic company that manufactures and sells kits for celiac serology

testing.

For many of us in the health care field, utilization management, and how most efficiently to use

laboratory testing in patient care is a critical issue.

While viewing this presentation, take some time to consider a few points, including how

this testing might be used in your practice, when the tests should be ordered, and how

the results from this testing might impact patient management.

Celiac disease is a chronic inflammatory condition that primarily affects the small intestine.

It is caused by an inflammatory response mounted by the patient's own immune system, which

ultimately results in damage and atrophy of the villae within the small intestine.

In the figure to the left on this slide, you see a biopsy of a normal small intestine,

with intact villae.

In the middle and right-most figures, you see the partial and total villous atrophy

that can occur in celiac disease as a result of the inflammatory response.

The clinical manifestations associated with celiac disease can be classified as gastrointestinal,

malabsorptive, or extra-gastrointestinal.

In the context of the gastrointestinal symptoms, patients may present with diarrhea, weight

loss, steatorrhea (fatty stool that can cause fecal incontinence), or abdominal pain, just

to name a few.

Because of the villous atrophy, patients with celiac disease may not be able to absorb nutrients

from their food.

As a result, patients may show symptoms of malabsorption, including iron-deficient anemia,

various vitamin deficiencies, hypoproteinemia (low protein levels in blood), or hypocalcemia

(low calcium levels in blood).

Young children may even present with a failure to thrive.

Lastly, patients with celiac disease may show manifestations that appear to have little

to do with the gastrointestinal system.

Reports in the literature have demonstrated associations between celiac disease and ataxia

(mobility issues), infertility, arthralgia (joint pain), dermatitis herpetiformis (chronic

blistering), hyposplenism (abnormal spleen function), and a variety of autoimmune conditions.

The point to stress here is that the symptoms of celiac disease may be nonspecific, sometimes

making for a challenging diagnosis.

For celiac disease to develop, an individual must have the both the genetic susceptibility

and the proper environmental exposure.

The genetic component of celiac disease had been inferred from observations that the disease

occurred in families.

Overall, in the United States, celiac disease occurs in approximately 1% of the total population.

In first-degree relatives of individuals with celiac disease, the prevalence increases to

10%.

Ultimately, specific alleles of the human leukocyte antigen complex, namely HLA-DQ2

and HLA-DQ8, were demonstrated to be responsible for much of the genetic susceptibility for

celiac disease.

The environmental component that causes celiac disease is dietary exposure to protein from

the cereal grains, namely wheat, barley, and rye.

Collectively, the protein agent from these cereal grains known to be associated with

celiac disease is gluten.

An initial diagnosis of celiac disease can be established if a patient has positive serology,

which I will expand on in a moment, and an intestinal biopsy that demonstrates villous

atrophy.

Once this initial diagnosis has been established, the patient will be started on a gluten-free

diet.

The goal of this treatment is to remove the environmental exposure of dietary gluten,

which is the trigger for the inflammatory response in the small intestine.

A definitive diagnosis of celiac disease can be established after gluten has been successfully

abolished from the diet.

The patient should begin to see resolution of their clinical symptoms, which is often

accompanied by conversion to a negative serology and reconstitution of the intestinal villae.

As I stated in the last slide, laboratory serology plays a key role in establishing

a presumptive diagnosis of celiac disease.

The primary antibodies associated with celiac disease are endomysial antibodies (or EMA);

tissue transglutaminase (or TTG) antibodies; and gliadin antibodies.

The antibodies against gliadin are related to the dietary gluten that initiates the inflammation

in celiac disease.

When the protein gluten is ingested, it is digested into smaller peptides.

The ethanol-soluble fraction of gluten is referred to as gliadin.

The first immunoassays developed tested for antibodies against unmodified gliadin.

However, these assays were inferior to the TTG antibody and EMA assays, and generally,

they were not recommended.

The newest generation of gliadin antibody assays uses a novel form of this antigen,

specifically deamidated gliadin.

These newer assays specific for deamidated gliadin offer improved diagnostic utility

and are preferred over assays using unmodified gliadin.

Testing for each of these antibodies can involve either assessing for IgA and IgG isotypes.

A variety of methodologies are available for these serology tests.

TTG and deamidated gliadin antibodies are generally detected using plate-based enzyme

immunoassays, although bead-based multiplex assays are becoming more common.

EMAs, on the other hand, are detected by immunofluorescent assays using some source of smooth muscle

tissue, such as a monkey esophagus substrate.

In addition to serology tests, genetic testing can be useful in the evaluation of a patient

with suspected celiac disease.

In this context, testing will focus on assessing for the presence of the HLA-DQ2 and HLA-DQ8

alleles.

Both the serologic and genetic testing can be important in establishing a diagnosis of

celiac disease.

However, it is important to appreciate the limitations of each type of testing.

For the serologic testing, we must deal with the issue of selective IgA deficiency.

Selective IgA deficiency is generally defined as the absence of detectable IgA immunoglobulin

in the presence of normal IgG and IgM production.

Although relatively rare, it is clearly more common in patients with celiac disease compared

with the general population.

In celiac diagnostic testing, the IgA isotype for the celiac-specific serologies is more

sensitive and specific compared to the IgG isotypes.

It is for this reason that the IgA isotype antibodies are preferred as a diagnostic test.

However, for patients with selective IgA deficiency, testing for the IgA isotype antibodies is

not useful, and testing for the IgG isotype antibodies is necessary.

The other issue that can impact the utility of the serology testing is the effect of a

gluten-free diet.

In a patient with celiac disease, removal of gluten from the diet leads to "down regulation"

of the inflammatory immune response, ultimately leading to reduced autoantibody production.

This is useful when monitoring patients with celiac disease, as decreasing concentrations

of the celiac-specific autoantibodies is interpreted as having a favorable response to the gluten-free

diet.

However, if a patient is already following a gluten-free diet before the diagnosis of

celiac disease has been established, there is a risk of a false-negative diagnostic serology

test.

Genetic testing for the celiac-associated HLA alleles also has some important caveats.

HLA-DQ2 is present in 90% to 95% of patients with celiac disease, while HLA-DQ8 is found

in the remaining 5% to 10%.

Because HLA-DQ2 and HLA-DQ8 are detected in virtually all patients with celiac disease,

it might appear that genetic testing would be the preferred diagnostic test for this

disorder.

Unfortunately, this is not the case because 30% to 40% of the general population of the

United States is positive for HLA-DQ2 and/or HLA-DQ8, yet, we must remember that only 1%

of the population has celiac disease.

So, what does this mean for the utility of HLA typing for celiac disease?

The power of the HLA testing lies in a negative result.

If a patient is negative for both HLA-DQ2 and HLA-DQ8, we can exclude celiac disease

as a diagnosis, since the patient does not have the genetic component, which is required

to develop the disease.

In contrast, if the patient is positive for either HLA-DQ2 or HLA-DQ8, we can only say

that the patient has the genetic susceptibility for celiac disease, although he or she may

never develop the disease in his/her lifetime.

At this point, I think it is important to summarize the test performance and clinical

utility of the various serologic and genetic tests used for the diagnosis of celiac disease.

The IgA isotypes for TTG and deamidated gliadin consistently have shown the best combination

of sensitivity and specificity.

EMA IgA generally demonstrates excellent specificity.

However, because EMA is performed by indirect immunofluorescence, this testing can have

some analytical challenges for the laboratory.

If we consider the IgG isotypes for TTG and deamidated gliadin, we find that they are

probably most appropriate for patients with a selective IgA deficiency.

And lastly, for HLA-DQ2 and HLA-DQ8, we find these to be most useful as a "rule-out test"

to exclude celiac disease as a diagnosis.

Given the variety of tests that are available for the diagnosis of celiac disease, choosing

the tests that are most appropriate for a given patient—not to mention interpreting

the results—can be a challenge.

The clinical labs at Mayo, working closely with our GI (gastrointestinal) colleagues,

have established several algorithms to aid in the diagnosis of celiac disease.

These algorithms involve reflexing of tests within the laboratory and are available as

orderable clinical tests.

No one algorithm is applicable to all patients being evaluated for celiac disease.

However, we believe that these various testing strategies will be useful for many patients

in a variety of situations.

The first cascade is the Celiac Disease Serology Cascade, or CDSP.

This algorithm is applicable to most patients and incorporates a reflex approach to serologic

testing.

The second cascade is the Celiac Disease Comprehensive Cascade, and has the test ID "CDCOM."

This algorithm includes both serologic and genetic testing.

Lastly, we have the Celiac Disease Comprehensive Cascade for Patients on a gluten-free diet,

or CDGF.

This cascade only performs serology in the context of a positive genetic test.

Now, I will go through each algorithm, beginning with the Serologic Cascade.

The Serologic Cascade begins with total IgA quantitation.

All further testing reflexes automatically within the lab, based on the IgA result.

The IgA result is classified as normal, or within the age-adjusted reference rage, as

low, being still detectable but below the reference range, or as deficient, or undetectable

by our nephelometric assay.

All samples with a normal IgA result would automatically reflex to a TTG-IgA antibody.

For all samples testing positive or negative, no further testing would be required.

The final report would include the total IgA and TTG-IgA results, along with an interpretive

comment.

However, if the TTG-IgA result falls into the equivocal range, then EMA and deamidated

gliadin-IgA testing is performed.

These results, along with the total IgA and TTG-IgA results would be included in the final

report.

On the other side of the cascade, those individuals who have no detectable IgA or have a selective

IgA deficiency would have TTG and deamidated gliadin testing performed but only the IgG

isotypes.

These results would be released as part of the final report, along with the total IgA

quantitation.

Finally, for those individuals with low but detectable IgA, TTG, and deamidated gliadin,

both IgA and IgG isotypes would be performed.

This cascade is designed to perform all testing necessary to identify patients who may have

celiac disease and in whom a biopsy would be suggested.

It is not applicable to patients who have been following a gluten-free diet, due to

the possibility of a false-negative serology test result.

The Comprehensive Cascade is identical to the Serologic Cascade except that HLA typing

is also performed.

The Comprehensive Cascade begins with both total IgA and HLA-DQ typing.

All further testing reflexes automatically within the lab based on the total IgA result

and occurs independent of the HLA result.

As far as the serology reflexing is concerned, the same pathways are followed as in the Serologic

Cascade.

The IgA results are classified as normal, low, or deficient.

For normal IgA, a TTG-IgA is performed.

For positive and negative results, no further testing is required.

If the TTG-IgA is weakly positive, EMA and deamidated gliadin-IgA are performed, the

results of which are included in the final report.

For individuals with selective IgA deficiency, testing for the IgG isotype for TTG and deamidated

gliadin antibodies is performed followed by the release of the final report.

For a low IgA result, both isotypes for TTG and deamidated gliadin are performed followed

by the interpretive report.

For a patient who has instituted a gluten-free diet in whom the diagnosis of celiac disease

has not been confirmed, the Comprehensive Cascade for Patients on a Gluten-Free Diet

may be appropriate.

In this algorithm, only the HLA-DQ typing is performed initially.

For those individuals who have neither the DQ2 nor DQ8 alleles, celiac disease is virtually

excluded as a diagnosis.

At this point, testing for celiac disease should stop, and other potential diagnoses

related to the patient's clinical presentation should be evaluated.

On the other hand, a positive result for DQ2 or DQ8 does not establish a diagnosis of celiac

disease—it means only that celiac disease is a possible diagnosis.

At this point, further testing should be performed, specifically all of the serologic tests.

Depending upon how long the patient has been following the gluten-free diet, and how strict

the diet is, some of these serologic tests may provide a positive result.

In that case, the interpretation would be that the results of all laboratory testing

are consistent with celiac disease and that a biopsy should be performed.

If all results are negative, celiac disease has not been completely ruled out, since this

could simply be a reflection of a successful gluten-free diet.

At this point, the clinician must determine how likely the diagnosis of celiac disease

is and if further evaluation, such as a gluten challenge, should be considered.

To summarize, Mayo Medical Laboratories offers three laboratory reflex algorithms for celiac

disease, which targets the most appropriate testing for the individual patient.

Each cascade has a specific utility.

The Celiac Disease Serology Cascade is the most widely applicable algorithm and uses

targeted serology testing for identification of patients in whom celiac disease is a possible

diagnosis and for whom a biopsy may be indicated.

The Celiac Disease Comprehensive Cascade includes serologic and genetic testing and is designed

for the small sub-set of patients in whom HLA-DQ2 and HLA-DQ8 typing is desired.

The Celiac Disease Comprehensive Cascade for Patients on a gluten-free diet relies on genetic

testing to exclude celiac disease in patients who have initiated a gluten-free diet prior

to a confirmed diagnosis of celiac disease.

One final point to mention is that all celiac testing offered by Mayo Medical Laboratories

is also available as individually orderable tests.

The testing algorithms are most useful for diagnostic evaluation, while the individual

tests are most appropriate for monitoring patients and their response to gluten-free

diets.

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Funny Ice Cream Shop Play, chocolate, melon,learn color,toy, RIWORLD - Duration: 4:51.

Here it is

I am RIWON~

Ice cream

So sweet Ice cream

Hello~

Oh little princess

What kind of ice cream do you want?

I like chocolate

Here you are

Thank you very much

How much is it?

1 dollar

Here you are

Thank you

So delicious

Ice cream

Ice cream

So sweet ice cream

Hello

Hello little princess

I like melon

Here you are

Thank you

How much is it?

1 dollar

Here you are

Thank you

So delicious

Ice cream

So sweet ice cream

Hello

Hello little princess

What kind of taste do you want?

I like strawberry

Here it is

Thank you

How much is it?

1 dollar

Here you are

Thank you

So delicious

So delicious

Oh ! The ice cream ended up on the floor.

I need to clean up

So delicious

I got it on my clothes.

I am so pretty

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DEFEATING GRAVITY ONCE AND FOR ALL | Dark Souls | Live Stream - Duration: 2:05:16.

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Hydro Jet Drain Cleaning Rancho Santa Margarita CA 800-538-4537 Hydro Jet Drain Cleaning - Duration: 1:06.

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For more infomation >> Hydro Jet Drain Cleaning Rancho Santa Margarita CA 800-538-4537 Hydro Jet Drain Cleaning - Duration: 1:06.

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[Zhao Yun] Ep. 18/18 - "Epilogue" | DYNASTY WARRIORS 8: EMPIRES - Duration: 25:03.

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[Zhao Yun] Ep. 16/18 - "Happy Go Lucky" | DYNASTY WARRIORS 8: EMPIRES - Duration: 8:24.

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[Zhao Yun] Ep. 17/18 - "Battle after Battle" | DYNASTY WARRIORS 8: EMPIRES - Duration: 25:32.

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Rotina WIM HOF completa (Banho frio + Respiração + Foco) - Duration: 7:57.

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How to get Adurite and Bars|Roblox Booga Booga! - Duration: 5:40.

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Roots and Reconnection - Interview | Voyages de reconnexion en Afrique - Duration: 37:16.

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SegMate Messenger Marketi...

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What Is Facemask Reconditioning | 2018 - Duration: 3:55.

[Jay] Welcome back, I'm Jay we've got Steve behind the camera. This is The Heads Up Show and today Steve, we're going over

reconditioning of individual masks, who's it for, why do you need it, and how to do it.

[Steve] Right so some people don't even know what face mask reconditioning is...so let's tell the people what it is.

[Jay] When you have a mask that is used and if it's showing any bare metal. Actually Steve, if it's showing

five points of bare metal or more it shouldn't be on the field. You gotta get that mask off the field.

Replace it or send it to us for reconditioning where we strip off the old material that's on there (down to the bare metal),

it's super clean, and then we put on a brand new coating just like it was from the factory

and then you get it back and it looks just like brand new or better

[Steve] It really, really does and we have a choice of 30 plus standard colors.

[Jay] 30 plus standard colors plus we can do any kind of chrome, hydro graphics, paint, you name it.

There's extra fees for all that stuff, but for a standard color Steve,

$30 which includes the return shipping back to you within the US.

[Steve] I have a face mask on my helmet, it's used, kind of banged up. I want to make it look new.

I take it off, I go to greengridiron.com.

[Jay] You click on the reconditioning tab

[Steve] OK

[Jay] Which you may have already found this video from clicking on that tab.

[Steve] Correct

[Jay] Once you click on that tab you'll see a PDF, you just print out the PDF,

You can either fill it out online then print it out, or you can print it and then handwrite it.

Just make sure you use neat handwriting because we need all of that information to make sure:

1) the mask gets done the right color that you want it,

and 2) everything gets sent back to you, so if you're messy...Steve, maybe you get

your sister, your brother, your mother, your father, your dog to fill it out for you.

[Steve] True

[Jay] Because we need your email address to make sure that we can email you if you have a question or to send you the tracking information

Make sure we actually have the physical address, and it's a correct full physical address.

Here in the United States Steve, they got this thing called zip codes. USE THEM!

So if you don't put a zip code or if you don't put the number of your house, it's not going to end up in the right place and it'll just delay the process.

[Steve] Let's say I'm on high school team and I'm part of 40 other or 50 other players, how does that work well?

[Jay] I would say give us a call.

[Steve] OK?

Because then we have a little bit more of a conversation,

obviously we have team pricing for orders that are over 25 masks

We we want to make sure we're getting you into the the order that's best for you.

Okay? [Steve] Correct

Allot of high schools, it's almost up to ten percent of the high schools out there, they'll change the color of

their helmet, their mask, their decals, their uniform, whatever it is from one year to the next,

or they're adding another color. We can help with all that stuff and

To make sure that you're getting the most economical and affordable solution

for whatever it is you're trying to do.

[Steve] And the team pricing is a pretty drastic discount as well.

[Jay] Team pricing is $15 for orders of 25 or more again, that's U.S. and that's standard colors.

So standard colors would be things like white, black, gray, navy, scarlet, dark green, purple, and there's a whole bunch more.

But if you have a mask Steve that's black,

and you send it to us for reconditioning, you don't have to get it black again, you can get it changed to white

and there's no excess charge for that because we have to strip it all the way down to the metal and put a new color on it anyway.

And say you're going, I don't know, from eighth grade to ninth grade

and your eighth grade team wears a green mask and your ninth grade team wears a black mask you

You love your mask, there's nothing wrong with it except for its beat-up or the color's wrong,

you can send it to us and get a brand new.

What looks like a brand new one.

[Steve] Cool. Very, very good. All right...well hopefully that clears things up.

That is facemask reconditioning in a nutshell.

And we do a lot of videos like this. How-To's, we do Helmet Builds, we talk about all the latest and greatest,

we work with a lot of the NFL, CFL, NCAA teams.

So we kind of have the little bit of extra access where we bring you things and we talk about things that you

might not be able to see every day, or you might not even know about. You probably learn a lot of stuff.

[Steve] It's true.

Click below, subscribe and we'll try and bring you the extra knowledge that we know.

Hope you like this video and cheers!

[Steve] Cheers

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