A lot of us grew up hearing that you can't regrow brain cells -- usually after we bumped
our head on something.
Scientists still debate whether that's actually true, but one thing's for sure: brains aren't
nearly as good at replacing cells as other parts of the body.
And when the brain gets damaged by something like a stroke, that damage stays instead of
getting fixed.
But a new study in the journal Nature Materials suggests a way of reversing that destruction.
For the first time, by injecting a specially made gel into mice, scientists were able to
successfully coax the mice's brains into growing back cells and structures that were
destroyed by a stroke.
And with millions of people suffering from the long-term consequences of strokes, this
could be a first step toward repairing their brains, too.
Strokes happen when blood is blocked from certain parts of the brain, cutting off oxygen
and nutrients and eventually killing the starved cells.
And if those cells do something important, like control your hands or safeguard your
memories, that job stops being done — which is why people who have had strokes can have
long-term memory issues or muscle control problems.
While interventions like physical therapy can sometimes significantly improve people's
symptoms by teaching the brain to find ways around the stroke's scar, there's always
a scar.
And for a little while, before that scar forms, there's basically a hole where the cells
once were.
That's because brains aren't as good at replacing dead cells as other organs — many
scientists say they can't naturally do it at all — so new neurons don't grow in
to fill the gap.
Adult human brains basically wall off the wounded area after cells die, keeping new
blood vessels from bringing in nutrients and oxygen and preventing the hole from filling
with the body's structural goo that supports cell growth.
Scientists with UCLA and Duke University wondered if they could design a material that would
essentially take that goo's place and—with any luck—help the brain heal.
What they came up with was a special kind of water-based gel which provides structure
to the empty space left by the cells.
They tried a few formulations, pitting the plain gel against ones with added goodies.
Those goodies included molecules that stimulate blood vessel growth and reduce inflammation,
which helps bring down barriers between the gel and the rest of the brain and allow nutrients
in to feed any new cells.
They gave mice strokes, then injected a tiny amount of gel into the holes left behind five
days later, with several mice receiving each formulation or nothing, as a control.
Afterwards, they checked in on the mice for weeks, both by looking at their actual brains
and by having them do certain kinds of physical tasks.
And over time, one thing became clear: one of their formulations was very effective.
Whole new structures including neural networks formed in the place of the stroke-killed cells,
and the mice mastered tasks their untreated counterparts couldn't.
But, there were some limitations to the study.
A big one is that the mice they used were young.
They were given strokes when they were more like teens than adults, so the experiments
happened as they grew into young adults — which is a stage in life when both mouse and human
brains are thought to be better at regrowing brain tissue, and not the age when strokes
usually occur.
So more research will need to be conducted on adult mice to see if their brains are also
able to benefit from the gel.
There's also the always important caveat that mice aren't people.
Even adult rodent brains seem to be better at growing neurons than adult human brains,
so what works for them might not work for us.
And the scientists still aren't sure exactly how the gel works, so they want to study it
further to figure more of that out.
So there's a lot to do before anything even approaching a human trial.
But, the fact that any gel formulation worked at all, let alone so well, makes the study
an exciting proof-of-concept.
And it's certainly a step in the right direction for millions of people who become disabled
by strokes every year.
Unfortunately, it's not all good news this week.
Because a paper in last week's issue of the journal Nature reports that someone, somewhere
in the world, apparently decided that the ozone layer is overrated, and has been releasing
alarming amounts of ozone-damaging CFCs into the atmosphere for the last few years.
"CFC" is short for "chlorofluorocarbon" -- a huge class of molecules that, as the
name implies, contain chlorine, fluorine, and carbon.
They were invented in the 1920s.
And at first, they seemed perfectly inert, which made them ideal for applications where
you don't want chemical reactions: Firefighting, pressurizing hairspray, cooling refrigerators
— you name it.
But when CFCs reach the upper atmosphere, they're broken down by ultraviolet light,
creating super-reactive pieces.
And those pieces eat away at our ozone layer, which is bad because that layer blocks a lot
of harmful radiation before it reaches the ground and does terrible stuff like cause
cancer in people or harm crops.
CFCs are also powerful greenhouse gases that trap thousands of times more heat than carbon
dioxide.
So they're not something you want in your atmosphere.
Which is why, in 1987, countries worldwide signed the Montreal Protocol, promising to
phase out CFCs over time and switch to less-destructive molecules.
Since then, atmospheric CFC concentrations have gradually dropped while the ozone layer
has gradually recovered.
But a new paper published last week reports that since about 2012, scientists have detected
far more CFCs in the atmosphere than there should be—about 13 million kilograms more.
Concentrations are still dropping worldwide, but not as much as they should be, which is
significantly slowing the progress of the last few decades.
And, maybe unsurprisingly, no one is taking credit.
The paper's authors have been monitoring the amount of CFCs in the atmosphere for a
long time, mostly by catching a bunch of air every once in a while and seeing what kinds
of molecules react with what's in the air.
And they noticed that around 2012, the rate of decline of CFCs slowed, suggesting a 25%
increase in emissions.
They didn't just automatically accuse people of violating the Montreal Protocol, though.
They considered other potential CFC sources before concluding that someone is making them.
They wondered if, maybe, buildings with a lot of CFCs in them were being demolished,
or if the way CFCs leave the atmosphere had changed, or if CFCs were trapped in ice that's
melting because of climate change.
But there's so muchunexpected CFCs that demolished buildings can't explain things.
And also, none of the other possibilities they considered fit the observations, because
it isn't just that CFC emissions in general have increased.
All of the new emissions are a specific kind of CFC called CFC-11 or trichlorofluoromethane.
And we don't know anything other than human production that would single out a single
CFC like that.
So the scientists had to conclude that humans are making and releasing new CFCs again, in
defiance of the Montreal Protocol.
But air in the atmosphere is so thoroughly mixed that, right now, no one can say where
the CFC-11 is coming from.
There are strong hints that it might be from eastern Asia, based on when winds brought
the new CFCs toward an observatory in Hawaii.
But that's about all they can say.
Getting a better idea of the source might require something like measurements from planes,
or closer analysis of any other chemicals that have also been increasing in the same
way, which might provide clues as to who's to blame.
For now, all we can say confidently is that someone is making new CFCs again, despite
how harmful we know they are.
If you're watching...stop!
And if you're not releasing new CFCs into the atmosphere, thank you for that, and for
watching SciShow!
If you want to keep up to date on all the latest news in science, make sure to click
on that subscribe button and check out all of our news episodes that we post every single Friday.
Also, if you're curious about the full history of CFCs, you might want to watch the episode
we did last year over on SciShow Space that's all about that.
For more infomation >> The New Gel That Regrows Brains - Duration: 7:50.-------------------------------------------
051918p3 - Duration: 24:39.
Its the Himura-san Happy Birthday Episode
Nogizaka Handmade Presents Championships
The members gave serious thought to their handmade birthday presents
and this is the 2nd half of Himura accepting their presents
First up its Shinuchi's handmade present
Its a Misanga
ah..misanga bracelet...you made this?
hai
No way!
I made it banana yellow
Its just that I kind of made it in a size that fits me
it may not work out
Try putting it on
I don't believe there's too much difference in peoples wrist sizes
Its long enough...look
Its really close
[ Not quite long enough ]
Not big enough?
I made another section
What did you just bring out?
I made an extension
Tighten it to this...then you can adjust it to any length you want
Are you good at making these?
I've been making them since middle school
I'd often make these during school
So if you take it off you'll die or something?
[ Cursed misanga? ]
The ojisan is making a face
[ Suddenly feeling anxious ]
ojisan with the worried look
Thats the same look when you go overseas and are pushed into buying something you don't want
[ Dead inside ojisan ]
Sticking out a bunch isn't it
This somehow or other isn't working out
This is not an appropriate length!
[ These adjustments are out of control ]
Its like something you'd use to ship out a package
[ Allows you to find his serial number? ]
Its like a tag with your serial number or something
Try putting it on his ankle, that should fit
Ankle style
Since it is summer
This really works
Ah, that's good
kawaii~
Yes, very fashionable
This is good, looks good
ah...that's good
You did something to me didn't you?
[ Comedical camerawork ]
Did something happen?
Camera-san is trying to be funny
But the ankle bracelet looks cool
kakkoii
[ From misanga to ojisan ]
You've done it again...oy
He's not doing anything....he's just panning up from your ankle
He's using funny timing or something
Don't use your pro timing on me!
That is a pro, he can't help that
Himura-san, make a wish for when it comes off
People often make wishes on bracelets that are supposed to come true when it breaks
I wish to get cast in a morning drama series!
[ He loves those morning dramas! ]
As the leading role
No way...leading actor is impossible
Himu-san
Hanbun, Himura
Next is Takayama's handmade present
I'll reveal it...open
ahhh, this is amazing
These are golf club headcovers
kawaii
What's this about?
I only did the embroidery, the rest of it was store bought
but I embroidered his name on here
You did the embroidery then?
hai
That [村] looks sloppy
The uneven surface kind of made it difficult
Since its Himura-san's birthday
when I was thinking about what I should get him
The other day on a show recording Sekine Tsutomu-san was sitting next to me
and it was for a 7 hour shoot
We have a Himura-san birthday episode coming up...what should I get him?
You went to Sekine-san for advice?
[ Getting someone important involved ]
Why would you get Sekine-san involved in this?
Sekine-san said
ah...so Himura-kun is into golf
I think headcovers would make a good gift
He gave me that advice
So then I went and bought this
This is amazing
I'm happy
I'm really going to use this
You have something else?
This is something added on the side, its not a big deal
Is it cash?
[ When all else fails, give cash? ]
If you'd like, please accept it
Moving out assistance voucher
So this...
*Limited to 1 use per voucher
So within Nogizaka what am I most effective at?
of course its my physical strength I think
So then when you're planning on moving out
I could help you with your move
Takayama
Himura-san just moved
He just moved out?!
sumimasen
Recently
Is that so
What's up with this voucher?
[ Unusable for the next several years ]
He just recently moved out
Really?....gomennasai
Since I just moved, there are still plenty of moving boxes
I'll take care of it
[ Also can be used for moving box cleanup ]
You'll unpack the moving boxes for him?
Yes, that's actually my specialty
Are you at the same level as the movers who do it by themself?
I see, movers can handle it themselves
since movers can do handle it by themselves
ojisan by himself plus Takayama then
And next is the handmade present from Hori
What? Painting?
Its a painting
[ What's going on...? ]
Lots of things I don't understand are happening right now
ah, that'll be enough
Hori
So this is a watercolor painting
Isn't it scary? What's this about?
It was my first time
trying to do a watercolor painting
What's the deal with his head?
My first time trying out this style of painting
I thought I wanted to try painting Himura-san
[ This just brings about more questions ]
There's meaning behind this
This is Himura-san as a blooming flower
[ The flower is Himura? ]
And then I painted this while listening to Kobukuro-san's [Tsubomi]
That's why that song was playing earlier?
[ 1 problem solved ]
Since Himura-san is bright like the sun and has that image
I used a lot of yellow and orange in the painting
Doesn't this Himura-san creep you out? Sorry if I offended you
You ok with this?
Since flowers can bloom in all kinds of places
Himura-san got married and is active doing variety shows
so you could say he can bloom anywhere
Got it
But isn't this Himura-san depressed looking?
Its a picture from an interview
I used that picture
Yes, his hair was parted down the middle...
Did I ever part my hair like that?
[ He doesn't even remember doing that ]
Why would you paint a rare version of Himura with his hair parted down the middle?
That's from an interview?
But this must have taken a lot of time
Took me about 5 hours
And you have some written text to go along with it
I really like writing poetry
Is this an additional present then?
A strong life force with warmth like the sun...
Himura continues to make all these epochs
You called him Himura
You've come up here and called him Himura
What's that about?
This part really stuck with me
Himura continues to make all these epochs
What's that mean?
Sounds like The Nonfiction
ikiteru~ ikiteiru~
The ever constant....epoch creating....Himura
Did you paint the frame as well?
No...I bought that at Tokyu Hands
When I went to Tokyu Hands-san
I bought a lot of art supplies to do this
You had to buy supplies
The frame and such...I asked a lot of people about what size to use
The store workers were giving me special treatment
They must have thought I was a famous painter
They probably weren't thinking that
[ More likely they knew she was a beginner ]
You must still have a lot of leftover supplies
There's a lot leftover
Keep painting then
Give us some other Himuras
ah I have to draw Himura-san?
If you painted Himura-san again, I think it would be interesting
No thanks
ah, you've done enough
I'm satisfied
Himura...you don't want to paint any more Himura?
That's enough Himura
[ Calling him Himura at the end also ]
This is terrifying
Its actually scarier than Ozono's present
That's going in the bedroom
The wife is going to put a stop to this
This is going next to the hugging pillow
Next is the handmade present from Yoda
open
Shoulder punch massage voucher
ah, its a voucher
When I was little, my father
he'd be so happy when I gave him a shoulder massage voucher
What's written on there?
What's this? This voucher can be used forever
So there's no limit on these?
None
That's crazy, you can get these for life
How about for each show recording?
This says Yoda will do this anytime I ask
Whether you have some free time or a day off
whatever you desire
[ All for Himura-sama ]
That sounded cute just now
Immediately Yoda maid will give out a shoulder massage
If you could
ready?
hai
ah yes, there's some power behind it
ohhh....wait
Wait...that hurts!
[ Shoulder assault? ]
Have you really done this before?
this shoulder massage
You're supposed to hit like this
Like this then
This one
Its like this or this or this
Himura has strong shoulders
How about like this?
How much strength would you like?
I need the stronger level
This won't work on Himura-san, he's frozen stiff
[ Misfit maid? ]
That didn't feel good at all
This voucher may never get used
Leave something for the end
Like this, but at the end you have to
TON
[ Finish button? ]
ah, that's not it?
ah gomen gomen
End it with a TON!
Kind of like a "FINISHED!"
Understand?
Try it
TON!
Who you calling a pig!
What is this?
TON!
What was that TON for?
Don't be adlibbing TON
And next is a handmade present from Eto
JAAAN
Sake...its sake!
hai
potato shochu
potato?
shochu
I love this stuff
This is potato shochu
Its Mao
ah...Mao
[ Premium shochu ]
I found out this is your favorite
This is the stuff
And then here
I thought of the bottle design
I added the lettering
It says Happy Birthday
as well as your birth day
Yuki
You can design it online, but for more detailed designs you have to call
Understood
I'm happy to receive this
arigatou
Eto, do you drink that?
I prefer barley shochu
Himura-san likes the potato
I like both potato and barley shochu
You like potato the best?
potato
Its potato
potato
Who you calling a potato?
The 3rd time you said potato sounded different
I'm just confirming you like potato shochu
I already said I like potato
potato
OY!
Now you've done it
You've crossed the line
arigatou...seriously this is good stuff
arigatou gozaimasu
So you came here
and actually gave him a normal present
[ One of the few with a conscience ]
But you're happy about that one
I am
And next is the handmade present from Terada
Its a bento
bento
bento?!
This bento is all fancy
Hold on, speaking of bentos
That's right
We had a bento episode
She had the super mini mini bento
And this time?
This time...since we're celebrating your birthday
I made you an interesting type of bento
Is that so
hai
Here goes
hai
This is wonderful
Himura-san...the tiny seawood rolls are back
[ The ultra tiny seaweed roll ]
This right
the seaweed rolls again
What's this?
That one in the middle
That's Himura-san
That's me
Its like
since this is a special celebration I thought a normal bento would be boring
so I did some bento research
Lately middle schoolers are known for being in their rebellious phase right
not just lately
Being in their rebellious phases the mothers
want some attention from their children so its popular to make bentos that irritate their kids
so then opening this bento and looking at Himura-san
its like using his face to creep the kids out
[ huh? ]
Seeing Himura-san's face and what now?
Since the bento is meant to annoy the child
the kid will open it and be annoyed, they want the kid to complain about it
What the heck are you saying all of a sudden!
[ There is no higher level of insult ]
They'll see Himura and be creeped out?
The mothers want their kids to complain about it
so I made a bento with Himura-san's face
I really did a lot of internet research on this
eh? So this really exists?
This is popular in today's society...
[ Cruel information on this special day ]
eh....sugoi
Yes, this really is amazing Himura-san
This will get parent and child talking again...they'll say today's bento was horrible
[ Intensifying the hurt ]
Its a way of using Himura-san
Did you know of this Himura-san?
I did not
I didn't know...this isn't something to say to someone on their birthday
That's true but
that's why I put the cheese heart on there
But I love you..
And how does that annoy your child bento taste?
ah...eating himself
Its good
oishii?
Its good
Try the side items Himura-san
Before I used karaage, but this is like [Chiki Chiki bone]
its like chicken wings
CHIKI CHIKI BONE
Let's call Himura-san CHIKI-CHIKI Bone from now on
No connection at all
Did you know they call Himura-san "Sol"
You know?
Comes from his wife
Its a transformation from the name Yuki
Yuu-kun
That [n] looks like a [so] in katakana
so Yuu-kyuso
Yuu-kyusol
Sol
[ Embarassing announcement ]
Now its just Sol
So when we go out to eat together
I casually blurted our Sol and he's like
huh? what?
That really surprised me..how dare he say it out loud
[ Sol has been exposed ]
Then it became "Sol! Sol!"
So then everyone call him Sol
[ Gradually allowing it to sink in ]
And next is the handmade present from Sakurai
huh?
What is this?
Now then Sakurai
Please open it up
wah...grass...well...
Its a plant...
Did you say that was grass?
Its a plant
huh? what's this about?
I brought a house plant that I've kept at my place
eh, this was in Sakurai's house?
[ Trying to dump it on him? ]
When you hear a senpai has a birthday
and you don't have a present, do you just grab something close?
[ Makeshift gift? ]
What's that about?
I took really good care of it but
its sort of not doing well
This thing is wilting
And why is it wilting?
For some reason its not doing well
I guess I'm unable to take care of it
but for Himura-san
I'm thinking you could make it healthy
Is this sort of thing even possible?
Your own house plant
this plant I've been taking care of is wilting so
I'll just give it as a birthday present
But you did take proper care of it?
For about 3 years
It should be fine then
You must have an attachment to it raising it for 3 years
Why are you giving it away?
Well with it being Himura-san's birthday
taking caring of this plant for 3 years
I'd like to entrust my child to Himura-san
She can't bring herself to say I took care of it but I don't want it anymore
That's not a bad thing
Its not something to be upset about
What should he do then? How often does he need to water it?
Once in awhile
[ huh? ]
What do you mean once in awhile? That doesn't mean anything
Himura-san won't be able to take care of it like this
About once a week?
Something like that
This is not something you'd normally bring from home
[ Since you're here, take care of this? ]
I don't know the answers either
I don't know how to make this plant well again
I believe its better to over water it, but I never did that
One time just try and take this to a florist
[ Determined to bring it to life ]
Its not that withered up, it should be fine
if you would
I'll take care of everything
[ Definitely give it happiness ]
And next is the handmade present from Matsumura
Yuki-kun
congratulations on your birthday
ah, you frightened me
Is that a pig?
[ Straight up insult? ]
This is too direct an insult
But since Himura-san is a pig
that's no reason to give him a pig
What's your problem?
You can put your hand inside
You play with it...its a puppet
ah, this is a puppet then
konnichiwa
I am Himura
So he is a pig
You pulled a fast one on me just now
[ She went all the way with it ]
Why would it say I am Himura
However there's a big secret along with this pig puppet
Somethings inside
ah...a letter?
Yes, that's actually the main gift
that's the main gift
I thought it would be good to put it inside
"Let's always be friends"
Let's please be friends
Along with that message
What? There's hair in here
That is Machu's hair
[ Shocking present ]
Whose hair is it? Matsumura's hair?
Hold on...what's this about
What's the meaning of this?
I want to be together with Himura-san forever
I wanted Himura-san to feel like I'm always there with him
What's up with that?
Are you being serious right now!?
[ If so, that's really messed up ]
Are you simply saying this contains part of your soul
In some way
Rather than saying its part of my soul
I simply wanted to give Himura-san some of my hair
[ This is wrong ]
OY!
Have you lost your damn mind!?
[ crazy girl ]
Not sure how you're supposed to react to that one
This is really something Matsumura
Since you're an official oniichan, going forward I'd like to be good friends
for many many years, you've been our friend for 7 years
I realize that
Moving forward
I'd like us to remain friends
I'll be your friend from now on...sure I will
But now because of this present, I don't think we can be friends
[ The terrifying lock of hair ]
She's thinking way out there
I can't even believe this....its remarkable
That's pretty interesting
You don't seem very pleased with my present
I've never experienced anything like this
My first time doing this
For Himura-san to be delighted with that present
OH YEAH!
I got some hair!
[ That's not happening ]
That would never happen
No it wouldn't
Up last is the handmade present from Ikuta
Here it is
hai
This is a smoothie
Why give this as your present?
Well of course being so busy, I wanted to give him something that would fill him with his daily nutrition
So you're treating him to an Ikuta original smoothie as a present
So you drink these often?
Nope....first time making one
[ Himura test subject ]
But its a smoothie, you can't mess up a smoothie
It can only be delicious with what I've brought with me
banana, kiwi, mango, apple
spinach and...
kale
kale, okra, mekabu seaweed
All healthy ingredients good for the body
I'd like to mix up all these ingredients
And with that Ikuta
takes a shot at making her first smoothie
These are really stringy ingredients
[ Huge portion of seaweed IN ]
You sure you want to put in that much seaweed
Since its green
What kind of reason is "since its green"
All green smoothies come out totally fine
There's seaweed sticking out of there...you sure about this?
[ mekabu seaweed...konnichiwa ]
You sure about letting the seaweed overflow
This is totally fine for you?
But you've never made one before
I've never done this before
Ikuta...Ikuta...Ikuta
Its not blending together at all
Don't you need to add water or something
milk?
You've never done this before right
I have never done this before
Too much! Too much!
The crowd is like "HEY! HEY too much!"
ah, its going
Yes!
Himura-san....Himura-san
She's making this for you Himura-san
Why are you making that face?
Ikuta's special smoothie is finished
and how will it taste?
ahhhh...so scary
Here goes
eh? Is it good?
wah!
Its good
Its good?
That's great
Totally...what is this
Its like
its like...edamame rice cake or something
[ Suddenly transforming into a solid ]
Like edamame rice cake?
There's a bunch of fruit in here
So it tastes like an edamame rice cake?
Its fruity edamame rice cake
Maybe because its green
But that must be pretty healthy
This is delicious
Thank goodness
I'm shocked
You thought it would bad?
To be honest, its very Ikuta-like
There's nothing disgusting in here, so I don't know how it could come out bad
That was my thinking...that's great
oishii
Aftertaste ok?
aftertaste isn't bad
Thank goodness
I do get the feeling this is healthy for me
Well then, please drink one every morning
This every morning?
I'm giving you this too
Giving me that?
hai
The smoothie gift is actually a mixer
I'm shocked...I'm getting a mixer
arigatou gozaimasu
sumimasen....arigatou
This 2nd part had people bringing things they no longer wanted
Himura-san gets all the unwanted goods
Why does Himura-san get them?
-------------------------------------------
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Detektivní seriál V.I.P. vraždy je věrný svému názvu. Jeho další díl se nese v záři slavných osobností jako jsou Iva Kubelková (41) a zpěvák Václav Noid Bárta (37)
Ten si užil roli rapera, který je obviněn z vraždy. K jeho image patří kožich, zlato na krku a krásné ženy, kdekoli se objeví
Nepřipomíná vám někoho? Leoš Mareš (42) a Rytmus (41) by si Václava Noida Bártu neměli v dalším díle V
I.P. vražd rozhodně nechat ujít!Václav Noid Bárta ztvárňuje ve své seriálové postavě rapera, který je obviněn z vraždy
Ke zlatu na krku, kožichu a kráskám si v rámci své role zapálil dokonce i doutník
A to už rok nekouří.„Musím říct, že natáčení bylo moc příjemné. Cítil jsem se tu jako doma, protože hudba, natáčení videoklipů, mít kolem sebe štáb – to je můj denní chleba
Kostymérky mi připravily krásné řetězy a kožich, kterého jsem si v době natáčení seriálu užil dost, byl můj třetí
V tu dobu jsem totiž hrál i v muzikálu Madagaskar, kde jsem jako král Jelimán, a v dalším muzikálu Sestra v akci taky jeden leopardí kousek mám
Ještě chvíli a myslím, že ten čtvrtý kožich by mi snad i narostl," smál se Noid.Ten si natáčení viditelně užíval
„Nejvíc mě bavily momenty, kdy mi na place připravili krásné americké auto, které bylo pro tu chvíli moje
Byl jsem jako král," rozplýval se Noid. ■
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